Predicting amyloid status in corticobasal syndrome using modified clinical criteria, magnetic resonance imaging and fluorodeoxyglucose positron emission tomography

Alzheimer's Research & Therapy
Sharon J ShaGil D Rabinovici

Abstract

Group comparisons demonstrate greater visuospatial and memory deficits and temporoparietal-predominant degeneration on neuroimaging in patients with corticobasal syndrome (CBS) found to have Alzheimer's disease (AD) pathology versus those with underlying frontotemporal lobar degeneration (FTLD). The value of these features in predicting underlying AD pathology in individual patients is unknown. The goal of this study is to evaluate the utility of modified clinical criteria and visual interpretations of magnetic resonance imaging (MRI) and fluorodeoxyglucose positron emission tomography (FDG-PET) for predicting amyloid deposition (as a surrogate of Alzheimer's disease neuropathology) in patients presenting with CBS. In total, 25 patients meeting CBS core criteria underwent amyloid (Pittsburgh compound B; PIB) PET scans. Clinical records, MRI, and FDG scans were reviewed blinded to PIB results. Modified clinical criteria were used to classify CBS patients as temporoparietal variant CBS (tpvCBS) or frontal variant CBS (fvCBS). MRI and FDG-PET were classified based on the predominant atrophy/hypometabolism pattern (frontal or temporoparietal). A total of 9 out of 13 patients classified as tpvCBS were PIB+, compared to 2out of 12 pa...Continue Reading

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Citations

Mar 11, 2016·Brain : a Journal of Neurology·Rik OssenkoppeleGil D Rabinovici
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Methods Mentioned

BETA
genotyping
biopsy

Software Mentioned

AAL Atlas
SPM8
SPSS
Predictive Analytics SoftWare
Statistical Parametric Mapping

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