Predicting antidepressant response using early changes in cognition: A systematic review

Behavioural Brain Research
Caroline ParkRoger S McIntyre

Abstract

Despite the widespread use of antidepressants in clinical practice, the current trial-and-error approach to medication selection contributes to treatment failure and underscores the need to identify reliable predictors of antidepressant response. Since changes in measures of cognition have been reported to occur early in treatment and prior to improvements in overall mood symptoms, the present review aims to determine whether early changes in measures of cognition can predict response in individuals with MDD. A systematic review of studies evaluating early cognitive change as a predictor of later treatment response in MDD was conducted using PubMed/Medline, Embase and PsychINFO. A total of seven articles were identified. The available evidence suggests the early changes in cognition may predict treatment response in individuals with MDD. This was shown across antidepressant classes (i.e., SSRIs, SNRIs, NRIs, melatonergic antidepressants) and forms of therapy (i.e., pharmacotherapy, rTMS). The results depict an emerging trend towards early changes in facial emotion recognition (i.e., a hot cognitive process) as a predictor of treatment outcome. Our qualitative analysis reflects a very limited number of studies. Moreover, there w...Continue Reading

Citations

Sep 11, 2019·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Xue-Dan NieJie Dong
Dec 20, 2018·Frontiers in Psychiatry·Hannah ZuckermanRoger S McIntyre
Apr 3, 2021·Multiple Sclerosis and Related Disorders·Jessica PoddaAndrea Tacchino
May 22, 2021·Brain and Neuroscience Advances·Joost HaarsmaSandra Tamm
Sep 4, 2021·Acta Neuropsychiatrica·Chen DrorHagai Maoz

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