Predicting arthritis outcomes--what can be learned from the Leiden Early Arthritis Clinic?

Rheumatology
D de RooyA van der Helm-van Mil

Abstract

In order to allow personalized medicine, adequate prediction of disease outcome is required. In early undifferentiated arthritis (UA), prediction of the development of RA is crucial, and in case of RA predicting the severity of the disease course may guide individualized treatment decisions. A total of 570 UA patients and 676 RA patients included in the Leiden Early Arthritis Clinic cohort were studied for baseline characteristics. The disease outcomes studied were fulfillment of the 1987 ACR-RA criteria and arthritis persistence in UA patients and the rate of radiological joint destruction and achieving sustained DMARD-free remission in RA patients. Predictive factors for fulfillment of the 1987 ACR-RA criteria and for persistent arthritis in UA were largely similar. Risk factors for a severe rate of joint destruction were: older age (P<0.001); male gender (P<0.001); longer symptom duration at first visit (P=0.048), involvement of lower extremities (P<0.001); BMI (P<0.001); high acute phase reactants, presence of IgM-RF (P<0.001); anti-CCP2 antibodies (P<0.001); anti-modified citrullinated vimentin antibodies (P<0.001) and HLA-DRB1 shared epitope alleles (P=0.001). A high BMI was associated with a lower rate of joint destructi...Continue Reading

References

Jan 1, 1983·Scandinavian Journal of Rheumatology·M NissiläS Sarna
Jan 20, 2004·Arthritis and Rheumatism·Jörg J GoronzyCornelia M Weyand
Sep 26, 2006·Nature Reviews. Immunology·Herbert Tilg, Alexander R Moschen
Oct 30, 2007·Annals of the Rheumatic Diseases·A H M van der Helm-van MilT W J Huizinga
Oct 31, 2007·Arthritis and Rheumatism·Gisela WesthoffAngela Zink
Apr 9, 2008·Arthritis Research & Therapy·Annette H M van der Helm-van Mil, Tom W J Huizinga
Sep 6, 2008·Arthritis Research & Therapy·Natacha CourvoisierBernard Combe
Mar 26, 2009·Current Opinion in Rheumatology·Naomi B KlarenbeekBen A C Dijkmans
Aug 1, 2009·Arthritis and Rheumatism·Michael P M van der LindenAnnette H M van der Helm-Van Mil
Oct 17, 2009·Arthritis Research & Therapy·Mohamed M ThabetAnnette H M van der Helm-van Mil

❮ Previous
Next ❯

Citations

Oct 12, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jing ShiLeendert A Trouw
Jan 20, 2012·Rheumatology·Diederik P C de RooyAnnette H M van der Helm-van Mil
Jan 5, 2013·Rheumatology·Annette H M van der Helm-van MilDouglas J Haney
Dec 18, 2013·International Journal of Rheumatic Diseases·Hyemin JeongHoon-Suk Cha
Oct 29, 2011·Arthritis Research & Therapy·Diederik P C De RooyAnnette H M Van der Helm-van Mil
Aug 21, 2012·Arthritis Research & Therapy·Mitra PikwerCarl Turesson
May 11, 2013·Annals of the Rheumatic Diseases·L E BurgersA H M van der Helm-van Mil
Apr 11, 2013·Annals of the Rheumatic Diseases·J A B van NiesA H M van der Helm-van Mil
Jun 3, 2014·Arthritis Research & Therapy·Rachel KnevelAnnette H M van der Helm-van Mil
Jan 7, 2014·Annals of the Rheumatic Diseases·D P C de RooyA H M van der Helm-van Mil
Apr 23, 2014·Arthritis Research & Therapy·Walter P MaksymowychAnthony Marotta
May 23, 2013·Annals of the Rheumatic Diseases·D P C de RooyA H M van der Helm-van Mil
Jun 4, 2014·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Silvano AdamiGiampiero Girolomoni
Jun 30, 2011·Current Rheumatology Reports·M Kristen Demoruelle, Kevin Deane
Sep 7, 2012·Annals of the Rheumatic Diseases·Jessica A B van NiesAnnette H M van der Helm-van Mil
Sep 8, 2012·Annals of the Rheumatic Diseases·Jessica A B van NiesAnnette H M van der Helm-van Mil
Apr 30, 2013·Annals of the Rheumatic Diseases·Hanna W van SteenbergenAnnette H M van der Helm-van Mil
May 23, 2012·Expert Review of Clinical Immunology·Ignacio Villa-Blanco, Jaime Calvo-Alén
Aug 6, 2014·Autoimmunity Reviews·Mathilde VersiniYehuda Shoenfeld
Nov 1, 2011·Autoimmunity Reviews·Ignazio OlivieriRoberto Caporali
Aug 7, 2014·Rheumatology·Elizabeth W KarlsonAnnette H van der Helm-van Mil
Dec 10, 2015·Rheumatology·Hanna W van Steenbergen, Annette H M van der Helm-van Mil
Jun 26, 2012·Arthritis Care & Research·Elisa GremeseUNKNOWN Gruppo Italiano di Studio sulle Early Arthritis (GISEA)
May 14, 2011·Arthritis and Rheumatism·Inge R Klein-WieringaAndreea Ioan-Facsinay
Mar 27, 2013·Arthritis and Rheumatism·R KnevelA H M van der Helm-van Mil
Oct 15, 2011·Statistics in Medicine·Roula TsonakaJeanine J Houwing-Duistermaat
Feb 27, 2013·Arthritis and Rheumatism·R KnevelA H M van der Helm-van Mil
Feb 10, 2011·Arthritis and Rheumatism·Cees M MeeuwisseAnnette H van der Helm-van Mil
Feb 28, 2014·Arthritis & Rheumatology·H W van SteenbergenA H M van der Helm-van Mil

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.