Predicting bone turnover following tobacco exposure using bone alkaline phosphatase and N-telopeptide biomarkers and possible variability and effect modification of these markers by race/ethnicity.

Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
Ogbebor E OmoikeKiana R Johnson

Abstract

Introduction: This study investigated the systemic response of serum bone alkaline phosphatase (SBAP) and urinary N-telopeptide (UNTX) to tobacco exposure and environmental tobacco smoke (ETS) and the possible effect modification (and variability) of this response by racial/ethnic origin.Methods: Data (n = 5411) were obtained from the National Health and Nutrition Examination Survey, with data analysis done on adults aged ≥ 20 years. Outcome variables were SBAP and UNTX. Independent variable was tobacco exposure measured using serum cotinine levels and adjusted for covariates. Generalized linear models were used to explore associations.Results: A percentage increase in log transformed serum cotinine was associated with a 0.005 percentage increase in log transformed SBAP (CI: 0.002, 0.008) and 0.02 percentage increase in log transformed UNTX (CI: -0.01, 0.04) with interaction between cotinine and race/ethnicity (p = 0.01). Stratifying by race/ethnicity, tobacco exposure was associated with significant decreases in UNTX among non-Hispanic Whites - 0.008(-0.014, -0.002) and Mexican Americans -0.014 (-0.025, -0.002) only. Categories of serum cotinine were associated with a monotonic increase in SBAP (p for trend <0.001) and monoton...Continue Reading

References

Jun 1, 1997·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·F CosmanM Parisien
Nov 20, 1998·MMWR. Morbidity and Mortality Weekly Report·UNKNOWN Centers for Disease Control and Prevention (CDC)
Aug 30, 2000·Bone·P B RapuriK L Ryschon
Aug 15, 2001·The Journal of Clinical Endocrinology and Metabolism·S S HarrisUNKNOWN Boston Low-Income Elderly Osteoporosis Study
Oct 31, 2001·Calcified Tissue International·K D Ward, R C Klesges
Mar 1, 2005·Pharmacological Reviews·Janne HukkanenNeal L Benowitz
Jun 21, 2007·The Journal of Clinical Endocrinology and Metabolism·Benjamin Z LederJohn B McKinlay
Feb 3, 2009·Handbook of Experimental Pharmacology·Neal L BenowitzPeyton Jacob
May 21, 2009·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Douglas C BauerUNKNOWN Osteoporotic Fractures in Men (MrOS) Research Group
Sep 23, 2009·Occupational and Environmental Medicine·A MacCarthyM F G Murphy
Aug 4, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·C J CrandallA S Karlamangla
Oct 1, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Katy J L BellDouglas C Bauer
Jun 6, 2012·Nature Reviews. Rheumatology·Kim Naylor, Richard Eastell
Aug 30, 2013·Journal of Translational Medicine·Gillian WheaterJacob M van Laar
Jan 9, 2014·Annals of Clinical Biochemistry·Thinn Thinn Hlaing, Juliet E Compston
Oct 20, 2017·European Journal of Endocrinology·Richard EastellNicola F A Peel
Jun 9, 2018·Journal of Exposure Science & Environmental Epidemiology·Susan MacPhersonMandy Fisher
Oct 31, 2018·Chronic Obstructive Pulmonary Diseases : Journal of the COPD Foundation·Young Ju SuhUNKNOWN COPDGene Investigators
Dec 7, 2018·MMWR. Morbidity and Mortality Weekly Report·James TsaiKatrina F Trivers
Jan 12, 2019·Journal of Osteoporosis·Ahmad M Al-BashairehSaunjoo Yoon
Jul 12, 2019·JAMA : the Journal of the American Medical Association·Douglas C Bauer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
T DeguchiH Miyazaki
Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Albert ShiehArun S Karlamangla
© 2022 Meta ULC. All rights reserved