Predicting cisplatin and trabectedin drug sensitivity in ovarian and colon cancers

Molecular Cancer Therapeutics
Ellen V StevensY Pommier

Abstract

Molecular profiling of markers involved in the activity of chemotherapeutic agents can shed light on the successes and failures of treatment in patients and can also provide a basis for individualization of therapy. Toward those ends, we have used reverse-phase protein lysate microarrays to evaluate expression of protein components of the nucleotide excision repair (NER) pathways. Those pathways strongly influence the anticancer activities of numerous drugs, including those that are the focus here, cisplatin and ecteinascidin 743 (Et-743; Yondelis, Trabectedin). Cisplatin is generally more active in cell types deficient in NER, whereas Et-743 tends to be less active in those cells. We measured protein expression and sensitivity to those drugs in 17 human ovarian and colon cancer cell lines (13 of them from the NCI-60 panel) and five xeroderma pigmentosum (XP) patient cell types, each containing a different NER defect. Of the NER proteins giving reliable signals, XPF and XPG showed the highest correlations of protein expression with drug activity across all three tissue-of-origin groups. When we compared protein expression data with mRNA expression data from Affymetrix U133A chips, we found no consistent correlation between the ...Continue Reading

References

Dec 1, 1996·Cancer Metastasis Reviews·R G OshimaC Caulín
Mar 4, 1997·International Journal of Cancer. Journal International Du Cancer·B KöberleJ R Masters
Jul 20, 1999·Journal of Medicinal Chemistry·M Zewail-Foote, L H Hurley
Mar 4, 2000·Nature Genetics·U ScherfJ N Weinstein
May 18, 2001·Nature·J H Hoeijmakers
Dec 31, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S ArnouldS Guichard
Nov 19, 2003·Proceedings of the National Academy of Sciences of the United States of America·Satoshi NishizukaJohn N Weinstein
Dec 6, 2003·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·E V StevensE C Kohn
Apr 20, 2004·International Journal of Cancer. Journal International Du Cancer·Carey WelshBeate Köberle
Oct 13, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E V StevensE C Kohn
Jan 22, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S MarchiniM D'Incalci
Mar 19, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Cristiana SessaNicoletta Colombo
Aug 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jaap Verweij
Sep 8, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Eddie Reed
May 25, 2006·Current Opinion in Oncology·Jérôme FayetteJean-Yves Blay
Sep 23, 2006·Nature Reviews. Cancer·Robert H Shoemaker
Nov 8, 2006·Molecular Cancer Therapeutics·John N Weinstein
Mar 7, 2007·Molecular Cancer Therapeutics·Uma T ShankavaramJohn N Weinstein
Jul 13, 2007·Nature Reviews. Cancer·Lloyd Kelland

❮ Previous
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Citations

Mar 9, 2010·Molecular Pharmaceutics·Ellen V StevensMark H Schoenfisch
Apr 2, 2009·Bioinformatics·E Shannon NeeleyKeith A Baggerly
Dec 30, 2009·Pharmacological Reviews·Marleen WelshM Eileen Dolan
May 13, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Mark S CareyBryan T Hennessy
May 6, 2010·Molecular Cancer Therapeutics·Hongfang LiuWilliam C Reinhold
May 19, 2010·Cell Division·Andrew JarnickiMatthias Ernst
Apr 18, 2009·Molecular Cancer Therapeutics·Philip L LorenziJohn N Weinstein
Jan 26, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Lauren Amable
Mar 23, 2011·Seminars in Oncology·Federico InnocentiM Eileen Dolan
Apr 5, 2014·Journal of the American Chemical Society·Marco Di AntonioShankar Balasubramanian
Oct 6, 2011·Proteomics·Maria StefanopoulouDirk A Wolters
Aug 2, 2011·International Journal of Cancer. Journal International Du Cancer·S UboldiM D'Incalci
Apr 15, 2016·Journal of Chemotherapy·Hirohiko YasuiNorifumi Naka
Dec 7, 2011·Small GTPases·Ellen V StevensChanning J Der
Aug 27, 2013·Critical Reviews in Oncology/hematology·Stéphane PuyoPhilippe Pourquier
May 21, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ho Sung LeeJi Hoon Jeong
May 6, 2014·Drug Discovery Today·Li-Ling LinUNKNOWN 2013 Taida Cancer Systems Biology Study Group
Jul 14, 2006·Genome Biology·Susanne PfoertnerRobert Geffers
May 15, 2009·Reproductive Biology and Endocrinology : RB&E·Oleg M AlekseevMichael G O'Rand
Jun 18, 2010·Expert Review of Anticancer Therapy·Josep M Del CampoAna Oaknin
Dec 23, 2016·Oncotarget·Kevin BrasseurEric Asselin
Apr 17, 2015·Journal of Biomolecular Screening·Rachel Doherty, Srinivasan Madhusudan
Oct 16, 2015·Journal of Gynecologic Oncology·Javier GayarreMaría J García
Apr 13, 2017·Journal of Hematology & Oncology·Audrey LarocheAntoine Italiano
Aug 28, 2020·Journal for Immunotherapy of Cancer·Michael Brandon WareGregory B Lesinski
Sep 12, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jana SlyskovaPavel Vodicka
Oct 25, 2011·Bulletin du cancer·Philippe Pourquier
Jan 7, 2009·Current Opinion in Obstetrics & Gynecology

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