Abstract
To determine whether baseline clinical and MRI features predict rate of clinical decline in patients with progressive apraxia of speech (AOS). Thirty-four patients with progressive AOS, with AOS either in isolation or in the presence of agrammatic aphasia, were followed up longitudinally for up to 4 visits, with clinical testing and MRI at each visit. Linear mixed-effects regression models including all visits (n = 94) were used to assess baseline clinical and MRI variables that predict rate of worsening of aphasia, motor speech, parkinsonism, and behavior. Clinical predictors included baseline severity and AOS type. MRI predictors included baseline frontal, premotor, motor, and striatal gray matter volumes. More severe parkinsonism at baseline was associated with faster rate of decline in parkinsonism. Patients with predominant sound distortions (AOS type 1) showed faster rates of decline in aphasia and motor speech, while patients with segmented speech (AOS type 2) showed faster rates of decline in parkinsonism. On MRI, we observed trends for fastest rates of decline in aphasia in patients with relatively small left, but preserved right, Broca area and precentral cortex. Bilateral reductions in lateral premotor cortex were as...Continue Reading
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Citations
Nov 21, 2018·American Journal of Speech-language Pathology·Rene L UtianskiKeith A Josephs
Nov 30, 2018·Clinical Linguistics & Phonetics·Katarina L Haley, Adam Jacks
Feb 2, 2019·Continuum : Lifelong Learning in Neurology·Hugo Botha, Keith A Josephs
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Mar 22, 2020·CNS Neuroscience & Therapeutics·Yingchuan ChenJianguo Zhang
Aug 7, 2020·American Journal of Speech-language Pathology·Rene L UtianskiKeith A Josephs
Aug 9, 2019·Movement Disorders Clinical Practice·Jennifer L WhitwellKeith A Josephs
Jan 22, 2021·Journal of Speech, Language, and Hearing Research : JSLHR·Rene L UtianskiKeith A Josephs
Mar 16, 2021·American Journal of Speech-language Pathology·Heather M ClarkKeith A Josephs
May 5, 2021·Journal of Neurology·Johnny DangHugo Botha
Jul 6, 2021·Aphasiology·Joseph R DuffyKeith A Josephs
Jul 23, 2021·Journal of the International Neuropsychological Society : JINS·Angelina J PolsinelliRene L Utianski
Sep 8, 2021·American Journal of Speech-language Pathology·Rene L UtianskiKeith A Josephs