Predicting cognitive decline in multiple sclerosis: a 5-year follow-up study

Brain : a Journal of Neurology
Anand J C EijlersJeroen J G Geurts

Abstract

Cognitive decline is common in multiple sclerosis and strongly affects overall quality of life. Despite the identification of cross-sectional MRI correlates of cognitive impairment, predictors of future cognitive decline remain unclear. The objective of this study was to identify which MRI measures of structural damage, demographic and/or clinical measures at baseline best predict cognitive decline, during a 5-year follow-up period. A total of 234 patients with clinically definite multiple sclerosis and 60 healthy control subjects were examined twice, with a 5-year interval (mean = 4.9 years, standard deviation = 0.9). An extensive neuropsychological evaluation was performed at both time points and the reliable change index was computed to evaluate cognitive decline. Both whole-brain and regional MRI (3 T) measures were assessed at baseline, including white matter lesion volume, diffusion-based white matter integrity, cortical and deep grey matter volume. Logistic regression analyses were performed to determine which baseline measures best predicted cognitive decline in the entire sample as well as in early relapsing-remitting (symptom duration <10 years), late relapsing-remitting (symptom duration ≥10 years) and progressive ph...Continue Reading

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Citations

Oct 12, 2019·Multiple Sclerosis : Clinical and Laboratory Research·Alfredo DamascenoFernando Cendes
Feb 19, 2020·Human Brain Mapping·Charidimos TsagkasStefano Magon
Oct 4, 2019·PloS One·Catherine A SpillingThomas R Barrick
Sep 6, 2020·Brain : a Journal of Neurology·Piet M BoumanJeroen J G Geurts
May 24, 2020·Current Neurology and Neuroscience Reports·Magdalena OsetMariola Matysiak
Feb 23, 2021·Frontiers in Neurology·Moein Amin, Daniel Ontaneda
Apr 4, 2021·Brain Sciences·Maria PetraccaVincenzo Brescia Morra
Jun 10, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Antonio CarotenutoFrancesco Saccà
Sep 28, 2021·Expert Review of Clinical Immunology·Deja R RoseDaniel Ontaneda
Mar 1, 2021·Reviews in the Neurosciences·Athina-Maria AloizouEfthimios Dardiotis

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