Predicting cognitive function from clinical measures of physical function and health status in older adults

PloS One
Niousha BolandzadehTeresa Liu-Ambrose

Abstract

Current research suggests that the neuropathology of dementia-including brain changes leading to memory impairment and cognitive decline-is evident years before the onset of this disease. Older adults with cognitive decline have reduced functional independence and quality of life, and are at greater risk for developing dementia. Therefore, identifying biomarkers that can be easily assessed within the clinical setting and predict cognitive decline is important. Early recognition of cognitive decline could promote timely implementation of preventive strategies. We included 89 community-dwelling adults aged 70 years and older in our study, and collected 32 measures of physical function, health status and cognitive function at baseline. We utilized an L1-L2 regularized regression model (elastic net) to identify which of the 32 baseline measures were strongly predictive of cognitive function after one year. We built three linear regression models: 1) based on baseline cognitive function, 2) based on variables consistently selected in every cross-validation loop, and 3) a full model based on all the 32 variables. Each of these models was carefully tested with nested cross-validation. Our model with the six variables consistently sele...Continue Reading

References

Dec 1, 1991·Journal of the American Geriatrics Society·S R LordI W Webster
Feb 1, 1991·Journal of the American Geriatrics Society·D Podsiadlo, S Richardson
Nov 1, 1990·Journal of Gerontology·M E TinettiL Powell
Jan 1, 1982·Journal of Psychiatric Research·J A YesavageV O Leirer
Jan 1, 1995·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·L E Powell, A M Myers
Mar 2, 1995·The New England Journal of Medicine·J M GuralnikR B Wallace
Oct 1, 1994·Journal of the American Geriatrics Society·S R LordK J Anstey
Feb 1, 1993·Journal of Clinical Epidemiology·R A WashburnC A Janney
Jun 1, 1993·Archives of Physical Medicine and Rehabilitation·L J RapportP S Abadee
Mar 1, 1997·Lancet·L Lundin-OlssonY Gustafson
Apr 1, 1998·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·M P van BoxtelJ Jolles
May 22, 1998·Neurology·R CamicioliJ Kaye
Jun 18, 1998·Archives of Physical Medicine and Rehabilitation·L J RapportS A Deshpande
May 22, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·C J DobbelsteynG Flowerdew
May 31, 2001·Journal of the American Geriatrics Society·S R Lord, J Dayhew
Oct 5, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·S R Lord, R C Fitzpatrick
Dec 14, 2002·Lancet·Karen Ritchie, Simon Lovestone
Jan 25, 2003·Medicine and Science in Sports and Exercise·Gaelle KervioNathalie S Ville
Feb 11, 2003·Chest·Paul L EnrightUNKNOWN Cardiovascular Health Study
May 6, 2003·Human Brain Mapping·Francine MalouinJulien Doyon
Jan 22, 2004·Nature Reviews. Neuroscience·Trey Hedden, John D E Gabrieli
Mar 20, 2004·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Reijo S TilvisTimo E Strandberg
Mar 27, 2004·Obesity Research·Berit L HeitmannLauren Lissner
Sep 4, 2004·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Hsu-Ko Kuo, Lewis A Lipsitz
Sep 24, 2004·JAMA : the Journal of the American Medical Association·Jennifer WeuveFrancine Grodstein
Mar 4, 2005·Journal of the American Geriatrics Society·Alesandro BleLuigi Ferrucci
Apr 9, 2005·Journal of the American Geriatrics Society·Ziad S NasreddineHoward Chertkow
May 10, 2005·Journal of Clinical Epidemiology·Dianne L GrollJames G Wright
Aug 5, 2005·Journal of the American Geriatrics Society·Stephen R LordCatherine Sherrington
Mar 17, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Shmuel SpringerJeffrey M Hausdorff
Apr 6, 2006·Neuropsychology·Roee HoltzerRichard B Lipton
Aug 18, 2006·Journal of the American Geriatrics Society·Kaarin J AnsteyMary A Luszcz
Jan 16, 2007·Neurobiology of Aging·Lisa MosconiMony J de Leon
Aug 19, 2007·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Hal H AtkinsonUNKNOWN Health ABC study
Oct 6, 2007·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Masatomo MiuraToshio Suzuki
Dec 7, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Galit Yogev-SeligmannNir Giladi
Jan 22, 2008·Nature·Wolfgang LutzSergei Scherbov
Mar 5, 2008·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·A M MyersW Sherk
Aug 5, 2008·The American Journal of Geriatric Pharmacotherapy·Howard FillitAndrea Zuckerman

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Citations

Jul 26, 2016·Frontiers in Psychology·Nina Skjæret-MaroniBeatrix Vereijken
Mar 23, 2017·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Elizabeth E DevoreSharon K Inouye
May 6, 2019·International Journal of Environmental Research and Public Health·Monika BłaszczyszynPaweł Pakosz
Mar 12, 2021·Age and Ageing·Claire C MeunierMichelle C Odden
Jun 15, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Joanna M BlodgettRebecca Hardy

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