Predicting complex phenotype-genotype interactions to enable yeast engineering: Saccharomyces cerevisiae as a model organism and a cell factory

Biotechnology Journal
Duygu DikiciogluStephen G Oliver

Abstract

There is an increasing use of systems biology approaches in both "red" and "white" biotechnology in order to enable medical, medicinal, and industrial applications. The intricate links between genotype and phenotype may be explained through the use of the tools developed in systems biology, synthetic biology, and evolutionary engineering. Biomedical and biotechnological research are among the fields that could benefit most from the elucidation of this complex relationship. Researchers have studied fitness extensively to explain the phenotypic impacts of genetic variations. This elaborate network of dependencies and relationships so revealed are further complicated by the influence of environmental effects that present major challenges to our achieving an understanding of the cellular mechanisms leading to healthy or diseased phenotypes or optimized production yields. An improved comprehension of complex genotype-phenotype interactions and their accurate prediction should enable us to more effectively engineer yeast as a cell factory and to use it as a living model of human or pathogen cells in intelligent screens for new drugs. This review presents different methods and approaches undertaken toward improving our understanding a...Continue Reading

References

Feb 11, 2016·Critical Reviews in Biotechnology·Mario Juhas, James W Ajioka
Sep 14, 2013·Biotechnology Journal·Diethard Mattanovich, Vassily Hatzimanikatis
Jan 30, 2015·Trends in Biotechnology·Francisco CarrauPablo S Aguilar
Oct 4, 2016·Metabolomics : Official Journal of the Metabolomic Society·D B Kell, Stephen G Oliver
Jul 17, 2018·Frontiers in Genetics·Lei Pei, Markus Schmidt

Citations

May 1, 1967·Journal of Bacteriology·L H Hartwell
Nov 7, 1981·Journal of Theoretical Biology·J D Ahlgren
Feb 1, 1994·Journal of Medical Genetics·A O Wilkie
Feb 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·J W ThatcherW J Dickinson
Feb 3, 1999·Annual Review of Genetics·J E Haber
Mar 18, 1999·Nature Genetics·Guri GiaeverRonald W Davis
Feb 9, 2002·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Reiner A Veitia
Mar 22, 2002·Nature·Lars M SteinmetzRonald W Davis
Apr 27, 2002·Applied and Environmental Microbiology·Jack T Pronk
Jun 14, 2002·Proceedings. Biological Sciences·Duncan GreigMichael Travisano
Jul 23, 2002·Nature Genetics·Lars M SteinmetzRonald W Davis
Feb 5, 2003·Genome Research·Jochen ForsterJens Nielsen
Jul 11, 2003·Nature·Balázs PappLaurence D Hurst
Oct 28, 2003·Proceedings of the National Academy of Sciences of the United States of America·Iman FamiliBernhard O Palsson
Feb 7, 2004·Science·Amy H Y TongCharles Boone
Feb 19, 2004·Nature Reviews. Genetics·Lars M Steinmetz, Ronald W Davis
Feb 20, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jian WuStephen G Oliver
Jul 9, 2004·Genome Biology·Bart Scherens, Andre Goffeau
Jul 20, 2004·Proceedings of the National Academy of Sciences of the United States of America·Robert G EasonViktor Stolc
Oct 22, 2004·Proceedings of the National Academy of Sciences of the United States of America·Sharyl L WongFrederick P Roth
Dec 14, 2004·Nature Genetics·Daniel SegrèRoy Kishony
Dec 30, 2004·Nature Genetics·Jason H Moore
Jan 22, 2005·Proceedings of the National Academy of Sciences of the United States of America·Rachel B Brem, Leonid Kruglyak
Feb 1, 2005·Trends in Genetics : TIG·Reiner A Veitia
Feb 18, 2005·Genetics·Adam M DeutschbauerGuri Giaever
Mar 31, 2005·Trends in Genetics : TIG·James A BirchlerReiner A Veitia
Apr 30, 2005·Trends in Pharmacological Sciences·Willem H Mager, Joris Winderickx
Jun 2, 2005·Evolution; International Journal of Organic Evolution·Clifford ZeylEmily Weninck

Related Concepts

Gene Dosage
Saccharomyces cerevisiae allergenic extract
Pathogenic Organism
Genes, Fungal
Organism
Biotechnology
Genetic Fitness
Fermentation
Biomedicine
Saccharomyces cerevisiae

Related Feeds

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.