Predicting conversion from MCI to AD by integrating rs-fMRI and structural MRI

Computers in Biology and Medicine
Seyed Hani HojjatiAlzheimer's Disease Neuroimaging Initiative

Abstract

Structural MRI (sMRI) and resting-state functional MRI (rs-fMRI) have provided promising results in the diagnosis of Alzheimer's disease (AD), though the utility of integrating sMRI with rs-fMRI has not been explored thoroughly. We investigated the performances of rs-fMRI and sMRI in single modality and multi-modality approaches for classifying patients with mild cognitive impairment (MCI) who progress to probable AD-MCI converter (MCI-C) from those with MCI who do not progress to probable AD-MCI non-converter (MCI-NC). The cortical and subcortical measurements, e.g. cortical thickness, extracted from sMRI and graph measures extracted from rs-fMRI functional connectivity were used as features in our algorithm. We trained and tested a support vector machine to classify MCI-C from MCI-NC using rs-fMRI and sMRI features. Our algorithm for classifying MCI-C and MCI-NC utilized a small number of optimal features and achieved accuracies of 89% for sMRI, 93% for rs-fMRI, and 97% for the combination of sMRI with rs-fMRI. To our knowledge, this is the first study that investigated integration of rs-fMRI and sMRI for identification of the early stage of AD. Our findings shed light on integration of sMRI with rs-fMRI for identification of...Continue Reading

Citations

May 12, 2019·GigaScience·Angela TamUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jul 2, 2020·Psychiatry and Clinical Neurosciences·Teruyuki MatsuokaUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jun 26, 2020·Frontiers in Neurology·R Scott TurnerBenedict C Albensi
Apr 29, 2020·Alzheimer's Research & Therapy·Peter N E YoungMichael Schöll
Sep 24, 2019·Frontiers in Neurology·Seyed Hani HojjatiAbbas Babajani-Feremi
Dec 11, 2020·The International Journal of Neuroscience·Hessam AhmadiAli Motie-Nasrabadi
Jan 15, 2021·Biomedical Physics & Engineering Express·Hessam AhmadiAli Motie-Nasrabadi
Feb 11, 2021·Computer Methods and Programs in Biomedicine·Hessam AhmadiAli Motie-Nasrabadi
Apr 6, 2021·Frontiers in Aging Neuroscience·David VogrincVita Dolžan
Aug 3, 2021·Computational Intelligence and Neuroscience·Morteza AminiMahshad Ouchani
Aug 15, 2021·NeuroImage·Jiahe ZhangSusan Whitfield-Gabrieli
Nov 2, 2021·ACS Chemical Neuroscience·Ying ZhouXiaoying Tang

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