Predicting critical closing pressure in children with obstructive sleep apnea using fluid structure interaction simulations.

Journal of Applied Physiology
Goutham MylavarapuRaouf S Amin

Abstract

Surgical treatment of obstructive sleep apnea (OSA) in children requires knowledge of upper airway dynamics, including the closing pressure (Pcrit), a measure of airway collapsibility. We applied a Flow-Structure Interaction (FSI) computational model to estimate Pcrit in patient-specific upper airway models obtained from magnetic resonance imaging (MRI) scans. We sought to examine the agreement between measured and estimated Pcrit from FSI models in children with Down syndrome. We hypothesized that the estimated Pcrit would accurately reflect measured Pcrit during sleep and therefore reflect the severity of OSA as measured by the obstructive apnea hypopnea index (AHI). All participants (n=41) underwent polysomnography and sedated sleep MRI scans. We used Bland Altman Plots to examine the agreement between measured and estimated Pcrit. We determined associations between estimated Pcrit and OSA severity, as measured by AHI, using regression models. The agreement between passive and estimated Pcrit showed a fixed bias of -1.31 (CI=-2.78, 0.15) and a non-significant proportional bias. A weaker agreement with active Pcrit was observed. A model including AHI, gender, an interaction term for AHI and gender and neck circumference expla...Continue Reading

References

Nov 17, 2007·Acta Anaesthesiologica Scandinavica·E HuupponenS Jääskeläinen
Nov 11, 2008·American Journal of Respiratory and Critical Care Medicine·Michael J BrennickRichard J Schwab
Nov 26, 2008·The Laryngoscope·Mihai MihaescuJ Paul Willging
May 27, 2009·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Michael FriedmanHsueh-Wen Chang
May 30, 2009·Adapted Physical Activity Quarterly : APAQ·Stamatis AgiovlasitisJeffrey J Widrick
Jun 9, 2009·Journal of Biomechanics·Goutham MylavarapuEphraim Gutmark
Dec 19, 2009·Paediatric Anaesthesia·Keira P MasonMark H Libenson
May 3, 2014·Sleep·María Luz Alonso-ÁlvarezDavid Gozal
Jul 29, 2015·Annals of Biomedical Engineering·Dhananjay Radhakrishnan SubramaniamEphraim J Gutmark
Sep 4, 2015·Journal of Biomechanics·Jernej PirnarIztok Žun
Sep 24, 2015·Pediatrics·Graziela De Luca CantoDavid Gozal
Mar 31, 2017·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Mohamed MahmoudRaouf S Amin
Nov 21, 2017·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Oluwaseun AkejuEmery N Brown
Jun 2, 2018·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·Kwang K ChangReza Movahed

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine
Pedro R GentaGeraldo Lorenzi-Filho
Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine
Mohamed MahmoudRaouf S Amin
© 2021 Meta ULC. All rights reserved