Predicting Cross-Reactivity and Antigen Specificity of T Cell Receptors.

Frontiers in Immunology
Chloe H LeeHashem Koohy

Abstract

Adaptive immune recognition is mediated by specific interactions between heterodimeric T cell receptors (TCRs) and their cognate peptide-MHC (pMHC) ligands, and the methods to accurately predict TCR:pMHC interaction would have profound clinical, therapeutic and pharmaceutical applications. Herein, we review recent developments in predicting cross-reactivity and antigen specificity of TCR recognition. We discuss current experimental and computational approaches to investigate cross-reactivity and antigen-specificity of TCRs and highlight how integrating kinetic, biophysical and structural features may offer valuable insights in modeling immunogenicity. We further underscore the close inter-relationship of these two interconnected notions and the need to investigate each in the light of the other for a better understanding of T cell responsiveness for the effective clinical applications.

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Citations

Jul 24, 2021·The Journal of Investigative Dermatology·Jörg Christoph Prinz

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Methods Mentioned

BETA
single cell sequencing
structure-based prediction
RNA-Seq
flow
proteomic profiling

Software Mentioned

NetMHCpan
TCRDist
VDJtools
ZAFFI
Expitope
FIMO
Kidera
TCRnet
IMGT V - QUEST
Find Individual Motif Occurrence ( FIMO )

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