Predicting diffusive alveolar oxygen transfer from carbon monoxide-diffusing capacity in exercising foxhounds.

Journal of Applied Physiology
Connie C W HsiaRobert L Johnson

Abstract

Although lung diffusing capacity for carbon monoxide (DL(CO)) is a widely used test of diffusive O2 transfer, few studies have directly related DL(CO) to O2-diffusing capacity (DL(O2)); none has used the components of Dl(CO), i.e., conductance of alveolar membrane and capillary blood, to predict DL(O2) from rest to exercise. To understand the relationship between DL(CO) and DL(O2) at matched levels of cardiac output, we analyzed cumulative data from rest to heavy exercise in 43 adult dogs, with normal lungs or reduced lung capacity following lung resection, that were studied by two techniques. 1) A rebreathing (RB) technique was used to measure Dl(CO) and pulmonary blood flow at two O2 tensions, independent of O2 exchange. DL(CO) was partitioned into CO-diffusing capacity of alveolar membrane and pulmonary capillary blood volume using the Roughton-Forster equation and converted into an equivalent DL(O2), [DL(O2)(RB)]. 2) A multiple inert-gas elimination technique (MIGET) was used to measure ventilation-perfusion distributions, O2 and CO2 exchange under hypoxia, to derive DL(O2) [DL(O2)(MIGET)] by the Lilienthal-Riley technique and Bohr integration. For direct comparisons, DL(O2)(RB) was interpolated to the cardiac output measur...Continue Reading

References

Jul 11, 1992·Journal of Applied Physiology·C C HsiaR L Johnson
Apr 1, 1992·Respiration Physiology·R B Reeves, H K Park
Jan 1, 1991·Journal of Applied Physiology·J I CarlinR L Johnson
Feb 1, 1991·Respiration Physiology·S C Hempleman, J M Hughes
Jan 1, 1990·Journal of Applied Physiology·C C HsiaR L Johnson
Dec 1, 1989·Journal of Applied Physiology·R O CrapoR E Forster
Mar 1, 1985·Journal of Applied Physiology·J R Torre-BuenoR E Moon
Apr 1, 1987·Respiration Physiology·P ScottoJ Piiper
Aug 1, 1987·Respiration Physiology·M D Hammond, S C Hempleman
Aug 1, 1988·Journal of Applied Physiology·J I CarlinR L Johnson
Sep 1, 1988·Respiration Physiology·S C Hempleman, A T Gray
Apr 1, 1985·Journal of Applied Physiology·K YamaguchiJ Piiper
Dec 15, 1966·The Japanese Journal of Physiology·M Mochizuki
Jun 1, 1969·Respiration Physiology·R A Holland
Dec 1, 1981·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·M MeyerJ Piiper
Aug 1, 1995·American Journal of Respiratory and Critical Care Medicine·C C HsiaM Ramanathan
Sep 1, 1995·Journal of Applied Physiology·C C HsiaR L Johnson
Jan 1, 1996·Respiration Physiology·S R HopkinsD C McKenzie
Jul 25, 2000·Journal of Applied Physiology·E Y WuR L Johnson
Feb 4, 2003·Journal of Applied Physiology·Connie C W HsiaRobert L Johnson
Jan 1, 1962·Journal of Applied Physiology·N C STAUBR E FORSTER
Feb 24, 2004·American Journal of Respiratory and Critical Care Medicine·Anagha R PhansalkarConnie C W Hsia
Oct 8, 2005·Journal of Applied Physiology·Paul McDonoughRobert L Johnson
Apr 8, 2006·Journal of Applied Physiology·D Merrill DaneRobert L Johnson
Nov 16, 1895·The Journal of Physiology·J Haldane
Dec 3, 1896·The Journal of Physiology·J Haldane, J L Smith
May 12, 1915·The Journal of Physiology·M Krogh
Aug 4, 2007·Journal of Applied Physiology·Connie C W HsiaPeter D Wagner
May 1, 1963·Journal of Applied Physiology·G M TurinoA P Fishman

❮ Previous
Next ❯

Citations

Dec 6, 2012·Pulmonary Medicine·Michael K SticklandMohit Bhutani
Apr 14, 2010·Respiratory Physiology & Neurobiology·Scott A SandsPhilip J Berger
Feb 22, 2014·Physiological Measurement·B VogtI Frerichs
Jul 3, 2019·Physiological Reports·Giovanni BarisioneVito Brusasco
Nov 9, 2012·The Journal of Experimental Biology·Tobias Wang, Hans Malte

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved