PMID: 38763Sep 1, 1979

Predicting drug-free improvement in schizophrenic psychosis

Archives of General Psychiatry
S R MarderW E Bunney


In a sample of 22 psychotic schizophrenic patients, eight improved substantially during a 30-day drug-free period. The drug-free improver group differed from the nonimprover group in demonstrating a later age of onset, briefer psychotic episodes, shorter hospitalizations, and better prognostic scores on the Phillips Scale, Strauss-Carpenter Modified Prognostic Scale, and the Vaillant Scale. After drug withdrawal, drug-free improvers frequently demonstrated further improvement when treated with doses of neuroleptic drugs that were substantially lower than the clinically recommended doses. The authors raise the question as to whether the drug-free improvers may represent a subgroup of schizophrenic patients who are being overtreated presently by standard neuroleptic practice.


Jan 1, 1989·Annals of the New York Academy of Sciences·D P van KammenK Goetz
Apr 1, 1984·Behavior Modification·R P LibermanB Stoute
Oct 17, 2006·The Journal of Nervous and Mental Disease·John Robert BolaVille Lehtinen
Oct 10, 2018·Journal of Clinical Psychopharmacology·Hideaki TaniHiroyuki Uchida
Oct 1, 1984·The Journal of the American Academy of Psychoanalysis·K Easton

Related Concepts

Individual Adjustment
Antipsychotic Effect
Psychotic Disorders
Dose-Response Relationship, Drug

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