Predicting early death in older adults with cancer

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Rabia BoulahssassOlivier Guerin

Abstract

Predicting early death after a comprehensive geriatric assessment (CGA) is very difficult in clinical practice. The aim of this study was to develop a scoring system to estimate risk of death at 100 days in elderly cancer patients to assist the therapeutic decision. This was a multicentric, prospective cohort study approved by an ethics committee. Elderly cancer patients aged older than 70 years were enrolled before the final therapeutic decision. A standardised CGA was made before the treatment decision at baseline. Within 100 days, event (death), oncologic and geriatric data were collected. Multivariate logistic regression was used to select the risk factors for the overall population. Score points were assigned to each risk factor using the β coefficient. Internal validation was performed by a bootstrap method. Calibration was assessed with the Hosmer-Lemeshow goodness of fit test and accuracy with the mean c-statistic. One thousand fifty patients (mean age: 82 years) joined the study from April 2012 to December 2014. The independent predictors were metastatic cancers (odds ratio [OR] 2.5; 95% confidence interval [CI], [1.7-3.5] p<0 .001); gait speed<0.8 m/s (OR 2.1; 95% CI [1.3-3.3] p=0.001); Mini Nutritional Assessment (MN...Continue Reading

Citations

Jul 25, 2019·Current Opinion in Oncology·Pierre-Louis Soubeyran, Raul Cordoba
Feb 5, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Frederic PamoukdjianFlorence Canoui-Poitrine
May 30, 2020·Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale·Paolo PisaniAngelo Zigliani
Jul 11, 2020·European Journal of Clinical Investigation·Domenico FuscoUNKNOWN Oncogeriatrics Group of the Italian Society of Gerontology, Geriatrics
Nov 28, 2019·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·P Mongiat-ArtusY Neuzillet
May 1, 2021·Journal of Clinical Medicine·Jaime FeliuMaría José Molina-Garrido
Dec 12, 2021·BMC Geriatrics·Qi ZhangUNKNOWN Investigation on Nutrition Status and its Clinical Outcome of Common Cancers (INSCOC) Group

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