Predicting Early Post-stroke Aphasia Outcome From Initial Aphasia Severity

Frontiers in Neurology
Alberto Osa GarcíaKarine Marcotte

Abstract

Background: The greatest degree of language recovery in post-stroke aphasia takes place within the first weeks. Aphasia severity and lesion measures have been shown to be good predictors of long-term outcomes. However, little is known about their implications in early spontaneous recovery. The present study sought to determine which factors better predict early language outcomes in individuals with post-stroke aphasia. Methods: Twenty individuals with post-stroke aphasia were assessed <72 h (acute) and 10-14 days (subacute) after stroke onset. We developed a composite score (CS) consisting of several linguistic sub-tests: repetition, oral comprehension and naming. Lesion volume, lesion load and diffusion measures [fractional anisotropy (FA) and axial diffusivity (AD)] from both arcuate fasciculi (AF) were also extracted using MRI scans performed at the same time points. A series of regression analyses were performed to predict the CS at the second assessment. Results: Among the diffusion measures, only FA from right AF was found to be a significant predictor of early subacute aphasia outcome. However, when combined in two hierarchical models with FA, age and either lesion load or lesion size, the initial aphasia severity was fo...Continue Reading

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Citations

Sep 15, 2020·The Clinical Neuropsychologist·Johémie BoucherSimona M Brambati
Apr 10, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Yun CaoJingling Chang
Apr 21, 2021·Scientific Reports·Michael IorgaTodd B Parrish
Jun 27, 2021·Brain Structure & Function·Robin GerritsGuy Vingerhoets
Nov 5, 2021·American Journal of Speech-language Pathology·Johémie BoucherSimona Maria Brambati

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