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Predicting evolutionary site variability from structure in viral proteins: buriedness, flexibility, and design

bioRxiv

Apr 24, 2014

Amir ShahmoradiClaus O Wilke

Abstract

Several recent works have shown that protein structure can predict site-specific evolutionary sequence variation. In particular, sites that are buried and/or have many contacts with other sites in a structure have been shown to evolve more slowly, on average, than surface sites with few...read more

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Computer Software
Molecular Dynamics
Study
Fluctuation
Viral Proteins
Site
Angular
Structure
Base Sequence
Simulation
4
9
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Predicting evolutionary site variability from structure in viral proteins: buriedness, flexibility, and design

bioRxiv

Apr 24, 2014

Amir ShahmoradiClaus O Wilke

PMID: 990004481

DOI: 10.1101/004481

Abstract

Several recent works have shown that protein structure can predict site-specific evolutionary sequence variation. In particular, sites that are buried and/or have many contacts with other sites in a structure have been shown to evolve more slowly, on average, than surface sites with few...read more

Mentioned in this Paper

Computer Software
Molecular Dynamics
Study
Fluctuation
Viral Proteins
Site
Angular
Structure
Base Sequence
Simulation
4
9

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