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Predicting evolutionary site variability from structure in viral proteins: buriedness, packing, flexibility, and design

bioRxiv

Apr 24, 2014

Amir ShahmoradiClaus O. Wilke

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Abstract

Several recent works have shown that protein structure can predict site-specific evolutionary sequence variation. In particular, sites that are buried and/or have many contacts with other sites in a structure have been shown to evolve more slowly, on average, than surface sites with few...read more

Mentioned in this Paper

Computer Software
Homologous Gene
Study
Molecular Dynamics
Simulation
Factor A
Site
Structure
Base Sequence
Viral Proteins
4
9
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  • Predicting evolutionary site variability from structure in viral proteins: buriedness, packing, flexibility, and design

    bioRxiv

    Apr 24, 2014

    Amir ShahmoradiClaus O. Wilke

    PMID: 990004481

    DOI: 10.1101/004481

    Abstract

    Several recent works have shown that protein structure can predict site-specific evolutionary sequence variation. In particular, sites that are buried and/or have many contacts with other sites in a structure have been shown to evolve more slowly, on average, than surface sites with few...read more

    Mentioned in this Paper

    Computer Software
    Homologous Gene
    Study
    Molecular Dynamics
    Simulation
    4
    9

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