Predicting frequent asthma exacerbations using blood eosinophil count and other patient data routinely available in clinical practice

Journal of Asthma and Allergy
David PriceChristine King

Abstract

Acute, severe asthma exacerbations can be difficult to predict and thus prevent. Patients who have frequent exacerbations are of particular concern. Practical exacerbation predictors are needed for these patients in the primary-care setting. Medical records of 130,547 asthma patients aged 12-80 years from the UK Optimum Patient Care Research Database and Clinical Practice Research Datalink, 1990-2013, were examined for 1 year before (baseline) and 1 year after (outcome) their most recent blood eosinophil count. Baseline variables predictive (P<0.05) of exacerbation in the outcome year were compared between patients who had two or more exacerbations and those who had no exacerbation or only one exacerbation, using uni- and multivariable logistic regression models. Exacerbation was defined as asthma-related hospital attendance/admission (emergency or inpatient) or acute oral corticosteroid (OCS) course. Blood eosinophil count >400/µL (versus ≤400/µL) increased the likelihood of two or more exacerbations >1.4-fold (odds ratio [OR]: 1.48 (95% confidence interval [CI]: 1.39, 1.58); P<0.001). Variables that significantly increased the odds by up to 1.4-fold included increasing age (per year), female gender (versus male), being overwe...Continue Reading

Citations

Jul 4, 2019·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·A ViinanenT Laitinen
Feb 25, 2020·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Daniel C GibbonsDavid Price
Mar 3, 2020·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Marjolein EngelkesKatia M C Verhamme
Dec 29, 2018·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Phoebe Tran, Lam Tran
Mar 28, 2017·Frontiers in Immunology·Gilda VarricchiGiorgio Walter Canonica
May 28, 2019·Frontiers in Pediatrics·Alan KaplanDavid Price
May 4, 2017·The European Respiratory Journal·Michael R EdwardsUNKNOWN members of the EARIP WP2 working group
May 1, 2021·International Journal of Molecular Sciences·Emanuela di PalmoAndrea Pession
May 1, 2021·International Journal of Molecular Sciences·Chiao-Juno Chiu, Miao-Tzu Huang
Jul 3, 2021·Journal of Asthma and Allergy·Trung N TranDavid B Price

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