PMID: 9537411DOI: 10.1038/ng0498-313Apr 16, 1998Paper
Predicting functions from protein sequences--where are the bottlenecks?
Nature Genetics
P Bork, E V Koonin
Abstract
The exponential growth of sequence data does not necessarily lead to an increase in knowledge about the functions of genes and their products. Prediction of function using comparative sequence analysis is extremely powerful but, if not performed appropriately, may also lead to the creation and propagation of assignment errors. While current homology detection methods can cope with the data flow, the identification, verification and annotation of functional features need to be drastically improved.
References
Aug 7, 1992·Science·M C KochT J Jentsch
May 7, 1992·Nature·S G OliverP Benit
Jul 23, 1992·Nature·P BorkE Sonnhammer
Oct 18, 1990·Nature·F P CremersH H Ropers
Apr 22, 1988·Cell·M KoenigL M Kunkel
Jun 1, 1970·Systematic Zoology·W M Fitch
Jun 1, 1995·Molecular Microbiology·P BorkP M Gillevet
Jan 1, 1995·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·J W Fickett
Oct 7, 1994·Science·Y MikiW Ding
Oct 1, 1995·Nature Genetics·M A Andrade, P Bork
Nov 17, 1995·Cell·N A EllisJ German
Oct 2, 1995·FEBS Letters·T MadejS H Bryant
Apr 1, 1995·Nature Genetics·F S Collins
Dec 1, 1994·Trends in Biochemical Sciences·P Bork, M Sudol
Dec 1, 1994·Nature·Y ZhangJ M Friedman
Sep 30, 1994·Science·M S BoguskiD E Bassett
Feb 1, 1994·Nature Genetics·S F AltschulJ C Wootton
Jan 25, 1993·Nucleic Acids Research·P M Sharp, A T Lloyd
Mar 19, 1993·Science·P GreenJ M Claverie
Dec 21, 1995·Nature·R WoosterG Micklem
Mar 1, 1996·Nature Genetics·E V Koonin
Mar 8, 1996·Science·V CampuzanoM Pandolfo
Apr 12, 1996·Science·C E YuG D Schellenberg
Mar 8, 1996·Cell·M SymonsA Abo
Apr 1, 1996·Nature Genetics·S BioneD Toniolo
Jun 15, 1996·Genes & Development·R Kolodner
May 1, 1996·Nature Genetics·P BorkM Nilges
Jul 1, 1996·Nature Genetics·E V KooninP Bork
Jan 1, 1996·Methods in Enzymology·P Bork, T J Gibson
Jan 1, 1996·Methods in Enzymology·J C Wootton, S Federhen
Jul 29, 1995·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·W M Fitch
Aug 15, 1996·Nature·M J MaciasH Oschkinat
Mar 1, 1996·Current Biology : CB·R L TatusovE V Koonin
Jan 1, 1996·Trends in Biochemical Sciences·C P PontingS J Winder
Aug 1, 1996·Genome Research·R F Smith
Nov 1, 1996·Nature Genetics·G ImbertA Brice
Oct 1, 1996·Trends in Genetics : TIG·P Bork, A Bairoch
Nov 1, 1996·Trends in Neurosciences·T J GibsonP Bork
Nov 26, 1996·Proceedings of the National Academy of Sciences of the United States of America·A N MonteiroH Hanafusa
Jan 2, 1997·FEBS Letters·I Callebaut, J P Mornon
Jan 1, 1997·Human Molecular Genetics·G BignellR Wooster
Jan 1, 1997·Protein Science : a Publication of the Protein Society·J SchultzP Bork
Dec 1, 1996·Trends in Biochemical Sciences·S K WuW E Balch
Jan 1, 1997·Trends in Biochemical Sciences·A Bateman
Mar 7, 1997·The Journal of Biological Chemistry·L A Tartaglia
Mar 27, 1997·Nature·A BergeratP Forterre
May 8, 1997·Nature·F ZhangR W Schevitz
May 23, 1997·Science·L ZhangK W Kinzler
Positionally cloned human disease genes: patterns of evolutionary conservation and functional motifs
May 27, 1997·Proceedings of the National Academy of Sciences of the United States of America·A R MushegianE V Koonin
❮ Previous
Next ❯
Citations
Jul 17, 2008·Comparative and Functional Genomics·A J PérezG Thode
Jul 29, 2009·Current Microbiology·Sergio HernándezEnrique Querol
Jan 8, 2009·Molecular Genetics and Genomics : MGG·Bhag Singh, Radhey S Gupta
Apr 6, 2005·Journal of Molecular Biology·Rajesh Nair, Burkhard Rost
Aug 27, 1999·Advances in Biophysics·O Gotoh
Nov 7, 2000·Progress in Biophysics and Molecular Biology·T L Blundell, K Mizuguchi
Nov 7, 2000·Progress in Biophysics and Molecular Biology·U HeinemannW Saenger
Nov 7, 2000·Progress in Biophysics and Molecular Biology·M Linial, G Yona
Nov 7, 2000·Progress in Biophysics and Molecular Biology·A Heger, L Holm
Nov 9, 2000·Molecular and Biochemical Parasitology·J D SmithL H Miller
Mar 24, 1999·Trends in Biotechnology·S SchusterD A Fell
Jun 23, 1998·Trends in Genetics : TIG·T DoerksP Bork
Dec 29, 1999·Nature Medicine
Jan 27, 2000·Trends in Genetics : TIG·E V Koonin
Nov 18, 2000·Gene·P StrippoliM Zannotti
Jun 19, 2001·Gene·O LecompteO Poch
Jun 14, 2002·Gene·Lorenza VitaleMaria Zannotti
Dec 3, 1998·Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie·J Frézal
May 30, 2001·Current Opinion in Genetics & Development·K R SreekumarE V Koonin
Jun 14, 2000·Current Opinion in Structural Biology·D T Jones
Jun 19, 2001·Current Opinion in Structural Biology·E V KriventsevaR Apweiler
Jul 20, 2002·Current Opinion in Structural Biology·Hidemasa Bono, Yasushi Okazaki
Jul 17, 1998·Current Opinion in Structural Biology·E V KooninM Y Galperin
Mar 27, 2001·Current Biology : CB·E V Koonin
Jun 12, 2003·Computational Biology and Chemistry·Cathy H WuWinona C Barker
Jun 3, 2000·Nature Biotechnology·M Y Galperin, E V Koonin
Jun 8, 2001·The Biochemical Journal·Y UedaK Shimotohno
Dec 15, 2000·Molecular Microbiology·D A RodionovM S Gelfand
Oct 13, 2005·Journal of Biomolecular Structure & Dynamics·S SandhyaN Srinivasan
Sep 6, 2001·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·X Gu
Mar 28, 2009·Briefings in Bioinformatics·Jeffrey Skolnick, Michal Brylinski
Feb 19, 2011·Briefings in Bioinformatics·Louis du PlessisChristophe Dessimoz
Nov 9, 2004·Bioinformatics·Johannes Söding
Jul 14, 2006·Bioinformatics·Kui LinDa-Yong Zhang
Sep 15, 2007·Bioinformatics·Alexis A RodriguezNatalia Maltsev
Oct 9, 2007·Bioinformatics·Matthew R HuskaMiguel A Andrade-Navarro
Apr 24, 2010·Bioinformatics·Bong-Hyun KimNick V Grishin
Oct 20, 2012·Bioinformatics·Shaul AshkenaziYanay Ofran
Nov 13, 2012·Bioinformatics·Richard RöttgerJan Baumbach
Dec 10, 1998·Nucleic Acids Research·C P PontingP Bork
Mar 29, 2000·Nucleic Acids Research·E Pérez-Rueda, J Collado-Vides
Jun 26, 2003·Nucleic Acids Research·C Z CaiY Z Chen
Dec 4, 2004·Nucleic Acids Research·Weidong TianJeffrey Skolnick
Dec 9, 2004·Nucleic Acids Research·L Y HanY Z Chen
Dec 21, 2004·Nucleic Acids Research·Sébastien AubourgAlain Lecharny
May 8, 2007·Nucleic Acids Research·Yi Zhou, Laura F Landweber
May 10, 2007·Nucleic Acids Research·Jake Gunn GlanvilleKimmen Sjölander
Oct 22, 2009·Nucleic Acids Research·Benjamin A ShoemakerAnna R Panchenko
Jul 8, 2011·Nucleic Acids Research·Lukasz JaroszewskiAdam Godzik
Dec 6, 2003·Genome Research·Thomas SchlittAlvis Brazma
❮ Previous
Next ❯
Related Concepts
Related Feeds
CRISPR Ribonucleases Deactivation
CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on mechanisms that underlie deactivation of CRISPR ribonucleases. Here is the latest research.
Related Papers
Bioinformatics
P D Karp
Trends in Genetics : TIG
T DoerksP Bork
Bioinformatics
Walter R GilksC A Ouzounis