Predicting future blood demand from thalassemia major patients in Hong Kong

PloS One
Eric H Y LauJoseph T Wu

Abstract

In Hong Kong, thalassemia major (TM) patients utilized up to 9.5% of blood supply in 2009. For long-term management of blood supply, we predicted the future blood demand of TM patients for the next 10 years. Annual individual transfusion data in 2005-2009 and demographic information of 381 TM patients were obtained from the Hong Kong Red Cross Blood Transfusion Service database. A generalized estimating equation (GEE) model was fitted to establish the potential relations of blood demand with age, sex, body weight, year of transfusion and splenectomy, accounted for within-patient correlation. The fitted model was used to predict future blood demand for the existing patients by accounting for expected change in body weight and mortality rate. We also predicted the number of new cases in the future based on age- and sex-specific TM incidence and official population projections. Future blood demand was predicted by combining blood demand from the existing and new patients. Female (RR = 0.94, p = 0.006) and history of splenectomy (RR = 0.85, p<0.001) were significantly associated with lower blood demand, while age and weight had an inverted U-shape relation with maximal blood demand at around 24 years of age and 71.8 kg, respectivel...Continue Reading

References

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Citations

Apr 22, 2015·Hemoglobin·Jamil M A S ObaidBasma H M Mersal
Apr 5, 2016·Hematology/oncology Clinics of North America·Yok-Lam KwongVivian Chan
Feb 14, 2019·Journal of Community Genetics·Sujata SinhaAlan H Bittles
Jul 22, 2019·Blood Reviews·Farrukh T ShahAntonio Piga
Mar 13, 2021·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Xiaolin SunYang Yu

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