Predicting gamma passing rates for portal dosimetry-based IMRT QA using machine learning

Medical Physics
Dao LamBaozhou Sun

Abstract

Intensity-modulated radiation therapy (IMRT) quality assurance (QA) measurements are routinely performed prior to treatment delivery to verify dose calculation and delivery accuracy. In this work, we applied a machine learning-based approach to predict portal dosimetry based IMRT QA gamma passing rates. 182 IMRT plans for various treatment sites were planned and delivered with portal dosimetry on two TrueBeam and two Trilogy LINACs. A total of 1497 beams were collected and analyzed using gamma criteria of 2%/2 mm with a 5% threshold. The datasets for building the machine learning models consisted of 1269 beams. Ten-fold cross-validation was utilized to tune the model and prevent "overfitting." A separate test set with the remaining 228 beams was used to evaluate model performance. Each beam was characterized by a set of 31 features including both plan complexity metrics and machine characteristics. Three tree-based machine learning algorithms (AdaBoost, Random Forest, and XGBoost) were used to train the models and predict gamma passing rates. Both AdaBoost and Random Forest had 98% of predictions within 3% of the measured 2%/2 mm gamma passing rates with a maximum error less than 4% and a mean absolute error < 1%. XGBoost showe...Continue Reading

References

Jun 3, 1998·Medical Physics·D A LowJ A Purdy
Oct 9, 2009·Medical Physics·Daniel W BaileyMatthew B Podgorsak
Mar 17, 2010·Medical Physics·Andrea L McNivenThomas G Purdie
Jul 6, 2010·NeuroImage·Ariana AndersonMark S Cohen
Nov 1, 2011·Australasian Physical & Engineering Sciences in Medicine·B W KingP B Greer
Nov 7, 2012·Medical Physics·Kelly C YoungeDonald A Roberts
Feb 8, 2013·Medical Physics·Andrea MolineuDavid Followill
May 3, 2013·Medical Physics·Daniel W BaileyMatthew B Podgorsak
Nov 22, 2013·Journal of Applied Clinical Medical Physics·Ann Van EschChristof Baltes
Feb 11, 2014·Medical Physics·Weiliang DuRajat J Kudchadker
May 9, 2014·Australasian Physical & Engineering Sciences in Medicine·S B CroweJ V Trapp
Sep 11, 2014·Journal of Applied Clinical Medical Physics·Jessie Y HuangStephen F Kry
Nov 20, 2015·International Journal of Radiation Oncology, Biology, Physics·John KangSushil Beriwal
Apr 3, 2016·Medical Physics·Jennifer M Steers, Benedick A Fraass
Jul 3, 2016·Medical Physics·G ValdesT D Solberg
Jul 28, 2016·Journal of Applied Clinical Medical Physics·Kelly C YoungeMartha M Matuszak
Aug 18, 2017·Journal of Applied Clinical Medical Physics·Gilmer ValdesTimothy D Solberg
Apr 1, 2018·Medical Physics·Yannet InterianGilmer Valdes
Sep 20, 2018·Physics in Medicine and Biology·Mallory C GlennStephen F Kry

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Citations

Nov 28, 2020·Physics in Medicine and Biology·Le WangJing Sui
Jan 19, 2021·Medical Physics·Nicholas J PotterGuanghua Yan
Mar 19, 2021·Frontiers in Artificial Intelligence·Maria F ChanGilmer Valdes
Mar 30, 2021·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Phillip D H Wall, Jonas D Fontenot
May 23, 2021·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Davide CusumanoLuca Indovina
Jun 29, 2021·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·L SimonP Meyer
Jul 8, 2021·Journal of Applied Clinical Medical Physics·Shadab MominXiaofeng Yang
Jun 25, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Ruijie YangJing Sui
Aug 4, 2021·Journal of Applied Clinical Medical Physics·Alexander F I Osman, Nabil M Maalej

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