Predicting geographic location from genetic variation with deep neural networks.

ELife
C.J. BatteyAndrew D. Kern

Abstract

Most organisms are more closely related to nearby than distant members of their species, creating spatial autocorrelations in genetic data. This allows us to predict the location of origin of a genetic sample by comparing it to a set of samples of known geographic origin. Here, we describe a deep learning method, which we call Locator, to accomplish this task faster and more accurately than existing approaches. In simulations, Locator infers sample location to within 4.1 generations of dispersal and runs at least an order of magnitude faster than a recent model-based approach. We leverage Locator's computational efficiency to predict locations separately in windows across the genome, which allows us to both quantify uncertainty and describe the mosaic ancestry and patterns of geographic mixing that characterize many populations. Applied to whole-genome sequence data from Plasmodium parasites, Anopheles mosquitoes, and global human populations, this approach yields median test errors of 16.9km, 5.7km, and 85km, respectively.

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Citations

Oct 7, 2020·Molecular Biology and Evolution·Alexander T XueUNKNOWN Ag1000g Consortium
Jan 10, 2021·Molecular Ecology·Thomas L SchmidtAry A Hoffmann
Jun 20, 2021·Science Advances·Garrett A Roberts KingmanKrishna R Veeramah
Jun 25, 2021·ELife·Matthew Js GibsonLeonie C Moyle
May 28, 2021·Molecular Ecology·Henry L NorthChris D Jiggins
Jul 17, 2021·Bioinformatics·Lily Agranat-TamirLiran Carmel

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Methods Mentioned

BETA
genotyping
PCAs
PCA

Software Mentioned

numpy
R
SPASIBA
R package adegenet
GATK
STRUCTURE
R Development Core Team
ADMIXTURE
PCA
SLiM

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