Predicting health-related quality of life (EQ-5D-5 L) and capability wellbeing (ICECAP-A) in the context of opiate dependence using routine clinical outcome measures: CORE-OM, LDQ and TOP.

Health and Quality of Life Outcomes
Jasmine PeakE J Frew

Abstract

Economic evaluation normally requires information to be collected on outcome improvement using utility values. This is often not collected during the treatment of substance use disorders making cost-effectiveness evaluations of therapy difficult. One potential solution is the use of mapping to generate utility values from clinical measures. This study develops and evaluates mapping algorithms that could be used to predict the EuroQol-5D (EQ-5D-5 L) and the ICEpop CAPability measure for Adults (ICECAP-A) from the three commonly used clinical measures; the CORE-OM, the LDQ and the TOP measures. Models were estimated using pilot trial data of heroin users in opiate substitution treatment. In the trial the EQ-5D-5 L, ICECAP-A, CORE-OM, LDQ and TOP were administered at baseline, three and twelve month time intervals. Mapping was conducted using estimation and validation datasets. The normal estimation dataset, which comprised of baseline sample data, used ordinary least squares (OLS) and tobit regression methods. Data from the baseline and three month time periods were combined to create a pooled estimation dataset. Cluster and mixed regression methods were used to map from this dataset. Predictive accuracy of the models was assesse...Continue Reading

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Citations

Dec 26, 2019·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Timea Mariann HelterJudit Simon
Jan 13, 2019·Health and Quality of Life Outcomes·Magdalena Millá-PerseguerRuth Usó-Talamantes
Sep 5, 2020·Substance Abuse Treatment, Prevention, and Policy·Christer Frode AasUNKNOWN INTRO-HCV Study Group
Feb 6, 2020·Substance Use & Misuse·Haya YasinMayyada Wazaify
Aug 10, 2021·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Fanni RenczValentin Brodszky

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Software Mentioned

OM
CORE
ICECAP
ICEpop

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