PMID: 9535150Apr 16, 1998Paper

Predicting high blood pressure in pregnancy: a multivariate approach

Journal of Hypertension
F Broughton PipkinS Lal

Abstract

To identify predictors of pregnancy-induced hypertension and pre-eclampsia in 212 nulliparous women before 20 weeks' gestation and at approximately 28 weeks' gestation. A randomized, prospective study in a teaching hospital. We performed standardized measurements of systolic and diastolic arterial blood pressures, body mass index, urinary calcium:creatinine ratio and components of the renin-angiotensin system, including platelet angiotensin II binding site density. Attending clinicians were blinded to the results. Outcome was assessed by one observer at the end of pregnancy. Discriminant function analysis was used to identify significant predictors. Fifty-five women had transient, presumed 'white-coat', systolic hypertension at the time of first pregnancy visit; they were twice as likely to develop pregnancy-induced hypertension and pre-eclampsia and five times more likely to deliver prematurely. Body mass index, platelet angiotensin II binding site density and urinary calcium:creatinine ratio measured before 20 weeks gestation were also significant predictors. At 28 weeks of pregnancy, measurements of the blood pressure were significant predictors (reflecting the near clinical expression of the disease), together with the plas...Continue Reading

References

Nov 1, 1978·American Journal of Obstetrics and Gynecology·E M Symonds, F Broughton Pipkin
Dec 1, 1976·American Journal of Obstetrics and Gynecology·E W Page, R Christianson
Aug 1, 1992·American Journal of Obstetrics and Gynecology·P N Baker, F Broughton Pipkin
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Citations

Jan 25, 2000·BJOG : an International Journal of Obstetrics and Gynaecology·F Broughton Pipkin
Aug 28, 2015·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Mami IshikuroYutaka Imai
Sep 25, 2001·American Journal of Obstetrics and Gynecology·M A BrownM Jones
Dec 4, 2012·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Louise DevismeDamien Subtil

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