Predicting infectious complications in neutropenic children and young people with cancer (IPD protocol).

Systematic Reviews
Robert S PhillipsPICNICC Collaboration

Abstract

A common and potentially life-threatening complication of the treatment of childhood cancer is infection, which frequently presents as fever with neutropenia. The standard management of such episodes is the extensive use of intravenous antibiotics, and though it produces excellent survival rates of over 95%, it greatly inconveniences the three-fourths of patients who do not require such aggressive treatment. There have been a number of studies which have aimed to develop risk prediction models to stratify treatment. Individual participant data (IPD) meta-analysis in therapeutic studies has been developed to improve the precision and reliability of answers to questions of treatment effect and recently have been suggested to be used to answer questions regarding prognosis and diagnosis to gain greater power from the frequently small individual studies. In the IPD protocol, we will collect and synthesise IPD from multiple studies and examine the outcomes of episodes of febrile neutropenia as a consequence of their treatment for malignant disease. We will develop and evaluate a risk stratification model using hierarchical regression models to stratify patients by their risk of experiencing adverse outcomes during an episode. We wil...Continue Reading

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Citations

May 11, 2013·Archives of Disease in Childhood·Bob PhillipsUNKNOWN PICNICC Collaboration
Dec 25, 2012·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·F GibsonUNKNOWN CCLG Supportive Care Group
Oct 16, 2015·Pediatric Radiology·Govind B ChavhanSue C Kaste
Nov 1, 2015·Journal of Communication Disorders·Heidi MartensMarc De Bodt
Jul 9, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Robert S PhillipsUNKNOWN PICNICC Collaboration
Jun 14, 2017·British Journal of Cancer·Gabrielle M HaeuslerRobert Phillips
Nov 7, 2019·Archives of Disease in Childhood·Bob PhillipsUNKNOWN PICNICC Collaborative
Mar 19, 2020·Archives of Disease in Childhood·Nicola SeneviratneRobert Phillips
Sep 5, 2012·Expert Review of Anti-infective Therapy·Gabrielle M Haeusler, Monica A Slavin

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