Predicting Inpatient Medication Orders From Electronic Health Record Data.

Clinical Pharmacology and Therapeutics
Kathryn RoughAlvin Rajkomar

Abstract

In a general inpatient population, we predicted patient-specific medication orders based on structured information in the electronic health record (EHR). Data on over three million medication orders from an academic medical center were used to train two machine-learning models: A deep learning sequence model and a logistic regression model. Both were compared with a baseline that ranked the most frequently ordered medications based on a patient's discharge hospital service and amount of time since admission. Models were trained to predict from 990 possible medications at the time of order entry. Fifty-five percent of medications ordered by physicians were ranked in the sequence model's top-10 predictions (logistic model: 49%) and 75% ranked in the top-25 (logistic model: 69%). Ninety-three percent of the sequence model's top-10 prediction sets contained at least one medication that physicians ordered within the next day. These findings demonstrate that medication orders can be predicted from information present in the EHR.

References

Oct 1, 1995·Annals of Emergency Medicine·K A RafteryA H Chen
Oct 23, 1997·Neural Computation·S Hochreiter, J Schmidhuber
Jan 3, 2008·JAMA : the Journal of the American Medical Association·Mark J PletcherRalph Gonzales
Jan 1, 2007·The International Journal of Biostatistics·M Alan Brookhart, Sebastian Schneeweiss
Jun 12, 2010·The New England Journal of Medicine·Yuting ZhangJoseph P Newhouse
Nov 5, 2010·The New England Journal of Medicine·Yuting ZhangJoseph P Newhouse
Jul 19, 2013·Journal of Patient Safety·John T James
Dec 21, 2013·Journal of Biomedical Informatics·Jeffrey G KlannGunther Schadow
Mar 29, 2014·Journal of the American Medical Informatics Association : JAMIA·Yiye ZhangJames E Levin
Apr 1, 2014·JAMA : the Journal of the American Medical Association·Paul MuntnerMonika M Safford
Sep 23, 2014·Journal of Biomedical Informatics·Aileen P WrightDean F Sittig
Jul 23, 2015·Journal of the American Medical Informatics Association : JAMIA·Jonathan H ChenRuss B Altman
Sep 23, 2016·Journal of the American Medical Informatics Association : JAMIA·Jonathan H ChenRuss B Altman
Nov 29, 2016·JAMA : the Journal of the American Medical Association·Nadine ShehabDaniel S Budnitz
Jan 21, 2017·Journal of the American Medical Informatics Association : JAMIA·Gordon D SchiffRonen Rozenblum
May 13, 2017·International Journal of Medical Informatics·Jonathan H ChenRuss B Altman
May 30, 2017·Health Care Management Science·Daniel GartnerRema Padman
Mar 14, 2018·JAMA : the Journal of the American Medical Association·Andrew L Beam, Isaac S Kohane
Dec 7, 2018·Annals of Internal Medicine·Alvin RajkomarMarshall H Chin
May 8, 2018·NPJ Digital Medicine·Alvin RajkomarJeffrey Dean

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Citations

Feb 16, 2021·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Allen J FlynnJames G Stevenson
May 20, 2021·Applied Clinical Informatics·Xinran LiuAtul J Butte

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