Predicting Inpatient Mortality Among Encephalitis Patients: A Novel Admission Risk Score

Open Forum Infectious Diseases
Michael HansenRodrigo Hasbun

Abstract

Identifying underlying commonalities among all-cause encephalitis cases can be extraordinarily useful in predicting meaningful risk factors associated with inpatient mortality. A retrospective cohort of patients with encephalitis was derived from a clinical chart review of adult patients (age ≥18 years) across 16 different hospitals in Houston, Texas, between January 2005 and July 2015. Clinical features at admission were assessed for their correlation with inpatient mortality and used to derive a final risk score prediction tool. The study included a total of 273 adult patients with all-cause encephalitis, 27 (9.9%) of whom died during hospitalization. A limited number of clinical features were substantially different between patients who survived and those who died (Charlson score, Glasgow coma scale [GCS], immunosuppression, fever on admission, multiple serologic studies, and abnormal imaging). A final multivariable logistic model was derived with the following risk factors, which were transformed into a scoring system: 1 point was assigned to the presence of a Charlson score >2, thrombocytopenia, or cerebral edema, and 2 points for a GCS value <8. Patients were then classified into different risk groups for inpatient mortal...Continue Reading

References

Jun 1, 1992·Journal of Clinical Epidemiology·R A DeyoM A Ciol
Jun 1, 1990·Archives of Neurology·B GordonR J Whitley
Feb 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R J Whitley, F Lakeman
Aug 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R T Johnson
Dec 1, 1996·Journal of Clinical Epidemiology·P PeduzziA R Feinstein
Jun 28, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Nino KhetsurianiLarry J Anderson
Jul 13, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Franck RaschilasFlore Rozenberg
Mar 11, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Carol A GlaserUNKNOWN California Encephalitis Project, 1998-2000
Jun 19, 2003·Journal of Clinical Epidemiology·Ewout W SteyerbergKarel G M Moons
Jun 28, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Allan R TunkelUNKNOWN Infectious Diseases Society of America
Jul 29, 2009·Clinical Medicine : Journal of the Royal College of Physicians of London·David J BellTom Solomon
Feb 18, 2010·Pediatric Neurology·Erin H BreeseDeborah K Sokol
Apr 3, 2010·Emergency Medicine Journal : EMJ·Benedict MichaelTom Solomon
Oct 19, 2010·The Lancet Infectious Diseases·Julia GranerodUNKNOWN UK Health Protection Agency (HPA) Aetiology of Encephalitis Study Group
Mar 19, 2011·BMC Bioinformatics·Xavier RobinMarkus Müller
Mar 31, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Alexandra MaillesUNKNOWN Steering Committee and Investigators Group
Nov 22, 2012·Epidemiology and Infection·S BernardUNKNOWN Steering Committee and Investigators Group
Jul 19, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A VenkatesanUNKNOWN International Encephalitis Consortium
Jul 31, 2013·Neurology·Kiran T ThakurArun Venkatesan
Nov 13, 2015·Expert Review of Neurotherapeutics·Margherita NosadiniRussell C Dale
Mar 18, 2016·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·S GennaiO Epaulard
Apr 19, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Rodrigo HasbunChristine C Ginocchio
Sep 14, 2017·BMC Health Services Research·Jessie CooperUNKNOWN ENCEPH-UK study group
Apr 8, 2018·Clinical Medicine : Journal of the Royal College of Physicians of London·Mark Ellul, Tom Solomon
Feb 21, 2019·Lancet·Arun VenkatesanTom Solomon
May 21, 2019·The Lancet Infectious Diseases·Esper G KallasYeh-Li Ho
Jul 12, 2019·Intensive Care Medicine·P JaquetUNKNOWN ENCEPHALITICA study group
Nov 30, 2019·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Corneliu Petru PopescuHakan Erdem

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Citations

Mar 21, 2021·Current Opinion in Infectious Diseases·Sonia Kaur Singh, Rodrigo Hasbun

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Methods Mentioned

BETA
IEC

Software Mentioned

R
boot
pROC

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