Predicting late anemia in critical illness

Critical Care : the Official Journal of the Critical Care Forum
Eric B MilbrandtDerek C Angus

Abstract

Identifying critically ill patients most likely to benefit from pre-emptive therapies will become increasingly important if therapies are to be used safely and cost-effectively. We sought to determine whether a predictive model could be constructed that would serve as a useful decision support tool for the pre-emptive management of intensive care unit (ICU)-related anemia. Our cohort consisted of all ICU patients (n = 5,170) admitted to a large tertiary-care academic medical center during the period from 1 July 2000 to 30 June 2001. We divided the cohort into development (n = 3,619) and validation (n = 1,551) sets. Using a set of demographic and physiologic variables available within six hours of ICU admission, we developed models to predict patients who either received late transfusion or developed late anemia. We then constructed a point system to quantify, within six hours of ICU admission, the likelihood of developing late anemia. Models showed good discrimination with receiver operating characteristic curve areas ranging from 0.72 to 0.77, although predicting late transfusion was consistently less accurate than predicting late anemia. A five-item point system predicted likelihood of late anemia as well as existing clinical...Continue Reading

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Citations

Nov 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·John M Higgins, L Mahadevan
Dec 7, 2010·The Journal of Trauma·Joseph A PoslusznyRichard L Gamelli
Dec 25, 2013·PloS One·Kun WangMichael Kirby
May 19, 2009·Critical Care Medicine·Anil K Agarwal
Jan 7, 2016·Molecular Medicine·Sergio I Valdés-FerrerKevin J Tracey
Dec 1, 2019·Burns : Journal of the International Society for Burn Injuries·Ren-Qi YaoZhao-Fan Xia

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