Predicting long-term renal and patient survival by clinicopathological features in elderly patients undergoing a renal biopsy in a UK cohort

Clinical Kidney Journal
Arunraj NavaratnarajahMichelle Willicombe

Abstract

Several publications have demonstrated the use of renal biopsy in elderly patients in establishing a diagnosis and enabling directed therapy. However, evidence on the long-term outcomes following biopsies is lacking. The aim of this study is to describe the renal and patient outcomes in elderly patients according to indication for biopsy, clinical parameters and the histological diagnosis. We performed a retrospective cohort study of 463 patients >70 years old who underwent a renal biopsy at our centre between 2006 and 2015. The median age of the patients was 74.8 (range 70.0-89.6) years. The most frequent primary diagnoses were pauci-immune crescentic glomerulonephritis (GN; 12%), acute interstitial nephritis (10.8%) and membranous GN (7.1%). Death-censored renal survival at 1 and 5 years following the index biopsy was 85.2 and 75.9%, respectively, and patient survival at 1 and 5 years was 92.2 and 71.6%, respectively. Patients who progressed to end-stage renal disease (ESRD) were at higher risk of dying compared with patients who did not require dialysis [hazard ratio 2.41 (95% confidence interval 1.58-3.68; P < 0.001]. On multivariate analysis, factors associated with the risk of progression to ESRD were creatinine (P < 0.00...Continue Reading

References

Mar 21, 1998·Kidney International·J C JennetteR J Falk
Feb 29, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M HaasS M Meehan
Feb 7, 2001·Transplantation·H U Meier-KriescheB Kaplan
Oct 22, 2003·Journal of the American Society of Nephrology : JASN·Chi-Yuan HsuMichael G Shlipak
Sep 15, 2007·Journal of the American Society of Nephrology : JASN·Ann M O'HareC Seth Landefeld
Nov 8, 2007·JAMA : the Journal of the American Medical Association·Josef CoreshAndrew S Levey
Nov 21, 2008·Journal of the American Society of Nephrology : JASN·Areef IshaniAllan J Collins
May 16, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Dimitrios-Anestis MoutzourisVivette D D'Agati
Jul 3, 2009·The New England Journal of Medicine·Laurence H BeckDavid J Salant
Jul 5, 2011·Journal of Nephrology·Catherine M BrownJohn J Walshe
Nov 18, 2011·Kidney International·Manjula Kurella TamuraAnn M O'Hare
Apr 21, 2012·Clinical Journal of the American Society of Nephrology : CJASN·Joseph R Berger, S Susan Hedayati
Oct 12, 2012·Clinical and Experimental Nephrology·Hitoshi YokoyamaUNKNOWN Committee for the Standardization of Renal Pathological Diagnosis and for Renal Biopsy and Disease Registry of the Japanese
Sep 4, 2014·Kidney International·Angela K MuriithiSamih H Nasr
Jan 22, 2015·Kidney International·Frank BridouxUNKNOWN International Kidney and Monoclonal Gammopathy Research Group
Jun 24, 2015·Clinical Journal of the American Society of Nephrology : CJASN·Maria WeinerMårten Segelmark
Jul 3, 2015·International Urology and Nephrology·Ozlem HarmankayaMehmet Hursitoglu
Sep 5, 2015·Clinical Journal of the American Society of Nephrology : CJASN·Jonathan J HoganJeffrey S Berns
Nov 26, 2016·BMC Nephrology·Agnieszka Perkowska-PtasinskaMagdalena Durlik

❮ Previous
Next ❯

Citations

Apr 17, 2020·Clinical Kidney Journal·Cynthia C LimJason Choo
Oct 10, 2020·PloS One·Ji-Young ChoiUNKNOWN on the behalf of The Korean GlomeruloNEphritis sTudy Group (KoGNET)
Nov 13, 2019·Néphrologie & thérapeutique·Aghilès HamrounFrançois Glowacki
Sep 11, 2021·Rheumatology·Gavin B ChapmanNeeraj Dhaun

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
biopsies
light microscopy
enzyme-linked immunosorbent assay

Software Mentioned

MedCalc

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.