Predicting mental disorders from hypothalamic-pituitary-adrenal axis functioning: a 3-year follow-up in the TRAILS study

Psychological Medicine
E NederhofJ Ormel

Abstract

Hypothalamic-pituitary-adrenal axis functioning, with cortisol as its major output hormone, has been presumed to play a key role in the development of psychopathology. Predicting affective disorders from diurnal cortisol levels has been inconclusive, whereas the predictive value of stress-induced cortisol concentrations has not been studied before. The aim of this study was to predict mental disorders over a 3-year follow-up from awakening and stress-induced cortisol concentrations. Data were used from 561 TRAILS (TRacking Adolescents' Individual Lives Survey) participants, a prospective cohort study of Dutch adolescents. Saliva samples were collected at awakening and half an hour later and during a social stress test at age 16. Mental disorders were assessed 3 years later with the Composite International Diagnostic Interview (CIDI). A lower cortisol awakening response (CAR) marginally significantly predicted new disorders [odds ratio (OR) 0.77, p = 0.06]. A flat recovery slope predicted disorders with a first onset after the experimental session (OR 1.27, p = 0.04). Recovery revealed smaller, non-significant ORs when predicting new onset affective or anxiety disorders, major depressive disorder, or dependence disorders in thre...Continue Reading

References

Jan 1, 1994·Psychoneuroendocrinology·C Kirschbaum, D H Hellhammer
Jun 15, 1999·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·A J ScheurinkP A Södersten
Feb 7, 2001·The British Journal of Psychiatry : the Journal of Mental Science·I M GoodyerP M Altham
Dec 5, 2000·The British Journal of Psychiatry : the Journal of Mental Science·I M GoodyerP M Altham
Dec 5, 2000·The British Journal of Psychiatry : the Journal of Mental Science·T O HarrisJ Herbert
May 5, 2004·Psychological Bulletin·Sally S Dickerson, Margaret E Kemeny
Aug 7, 2004·International Journal of Methods in Psychiatric Research·Ronald C Kessler, T Bedirhan Ustün
Nov 27, 2004·Psychosomatic Medicine·Tara L GruenewaldJohn L Fahey
Mar 29, 2005·European Journal of Epidemiology·Andrea F de WinterJohan Ormel
Sep 19, 2006·Journal of Clinical Epidemiology·A Rogier T DondersKarel G M Moons
Sep 29, 2006·Sports Medicine·Esther NederhofTheo Mulder
Mar 4, 2008·Psychophysiology·Frouke E P L SondeijkerFrank C Verhulst
Apr 9, 2008·Brain, Behavior, and Immunity·J M Koolhaas
Jul 9, 2008·Stress : the International Journal on the Biology of Stress·Moïra MikolajczakPhilippe de Timary
Aug 16, 2008·British Journal of Sports Medicine·R MeeusenM F Piacentini
Oct 16, 2008·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Eva FriesClemens Kirschbaum
Mar 3, 2009·Journal of the American Academy of Child and Adolescent Psychiatry·Ronald C KesslerKathleen R Merikangas
Mar 6, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Uma RaoRussell E Poland
Jul 2, 2009·The British Journal of Psychiatry : the Journal of Mental Science·Ian M GoodyerJoe Herbert
Feb 9, 2011·Archives of General Psychiatry·Benjamin B LaheyPaul J Rathouz
Feb 15, 2011·Neuroscience and Biobehavioral Reviews·J M KoolhaasE Fuchs
Feb 19, 2011·Journal of Affective Disorders·Mark A EllenbogenCaroline S Ostiguy
Jul 15, 2011·Psychoneuroendocrinology·Darlene A Kertes, Manfred van Dulmen
Dec 20, 2011·PLoS Medicine·Judith G M Rosmalen, Albertine J Oldehinkel
Jun 29, 2013·Stress : the International Journal on the Biology of Stress·Robin LawAngela Clow
Nov 19, 2013·Neuroscience and Biobehavioral Reviews·Andrew P AllenGerard Clarke
Sep 23, 2014·Journal of Personality and Social Psychology·Aleksandr KoganDacher Keltner
Nov 2, 2014·Clinical Psychological Science : a Journal of the Association for Psychological Science·Avshalom CaspiTerrie E Moffitt

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Citations

Apr 16, 2014·Journal of Personality·Odilia M LaceulleJohan Ormel
May 8, 2015·Psychoneuroendocrinology·Lisette J van der KnaapHarriëtte Riese
Feb 1, 2017·Scientific Reports·Maximus BergerZoltán Sarnyai
Feb 20, 2020·Stress : the International Journal on the Biology of Stress·S KetheesanZ Sarnyai
Jun 11, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Boushra DalileLukas Van Oudenhove
Dec 21, 2017·Stress : the International Journal on the Biology of Stress·Meghan E QuinnEmma K Adam
Apr 21, 2019·Psychiatry Research·Elisabeth C D van der StouweSanne H Booij
Nov 6, 2020·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Marlee R SalisburyLeslie E Roos

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