Predicting Mid-term All-cause Mortality in Patients Undergoing Elective Endovascular Repair of a Descending Thoracic Aortic Aneurysm

Annals of Surgery
Benjamin O PattersonMatt M Thompson

Abstract

All-cause mortality in patients after repair of aortic aneurysms of the descending thoracic aorta thoracic endovascular aortic repair (TEVAR) is relatively high at mid-term follow-up. The aim of this study was to derive and validate a system that could predict all-cause mortality after TEVAR to aid with patient selection. The MOTHER database contained 625 patients that underwent elective surgery for descending thoracic aortic aneurysms. Univariate analysis identified preoperative factors associated with mid-term all-cause mortality, and a Cox proportional hazards model was developed. The model was internally validated using Kaplan-Meier comparison of observed vs predicted mortality. External validation was performed using a data set from the University of Florida College of Medicine. There were 625 patients that underwent TEVAR for descending thoracic aortic aneurysm in the MOTHER database and 231 in the University of Florida College of Medicine validation set. The mid-term mortality rate at 6 years of follow-up was 34.4% and 34%, respectively. The all-cause mortality risk score was calculated using 0.0398 × (age) + 0.516 × (renal insufficiency) + 0.46 × (previous cerebrovascular disease) + 0.352 × (prior tobacco use) + 0.376 ×...Continue Reading

References

Dec 22, 2006·American Journal of Epidemiology·Eric Vittinghoff, Charles E McCulloch
Mar 21, 2008·Journal of Vascular Surgery·Michel S MakarounUNKNOWN Gore TAG Investigators
Jun 24, 2008·Journal of Vascular Surgery·Ronald M FairmanUNKNOWN VALOR Investigators
Oct 17, 2008·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·B O PattersonM M Thompson
May 30, 2009·BMJ : British Medical Journal·Douglas G AltmanKarel G M Moons
Jul 6, 2010·Journal of Vascular Surgery·Jayer ChungElliot L Chaikof
Oct 19, 2010·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·UNKNOWN Virtue Registry Investigators
Mar 4, 2011·Journal of Vascular Surgery·Stuart B PrennerPeter L Faries
May 2, 2012·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Robin H HeijmenKarl Heinz Orend
Jul 14, 2012·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Tamer GhatwaryPeter J Holt
Jul 27, 2012·Journal of Vascular Surgery·Ronald M FairmanUNKNOWN VALOR II Investigators,
Jan 3, 2013·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·R S von AllmenJ T Powell
Oct 5, 2013·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·A KarthikesalingamM M Thompson
Mar 19, 2014·Journal of Vascular Surgery·Jon S MatsumuraUNKNOWN Zenith TX2 Clinical Trial Investigators
May 20, 2014·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·S W GrantC N McCollum

❮ Previous
Next ❯

Citations

Oct 18, 2016·The British Journal of Surgery·B O PattersonP J Holt
Dec 12, 2018·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Massimiliano M Marrocco-TrischittaSanti Trimarchi
Jun 5, 2021·The Cochrane Database of Systematic Reviews·Ala ElhelaliFionnuala Jordan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aneurysm

Aneurysms are outward distensions or bulges that occurs in a weakened wall of blood vessels. Discover the latest research on aneurysms here.

Aortic Aneurysm

An aortic aneurysm is the weakening and bulging of the blood vessel wall in the aorta. This causes dilatation of the aorta, which is usually asymptomatic but carries the risk of rupture and hemorrhage. Find the latest research on aortic aneurysms here.

Cardiac Aneurysm

Aneurysm refers to a bulge of the wall or lining of a vessel commonly occurring in the blood vessels at the base of the septum or within the aorta. In the heart, it usually arises from a patch of weakened tissue in a ventricular wall, which swells into a bubble filled with blood. Discover the latest research on cardiac aneurysm here.