Predicting mortality in adult patients with sepsis in the emergency department by using combinations of biomarkers and clinical scoring systems: a systematic review.

BMC Emergency Medicine
Kirby Tong-MinhYuri van der Does

Abstract

Sepsis can be detected in an early stage in the emergency department (ED) by biomarkers and clinical scoring systems. A combination of multiple biomarkers or biomarker with clinical scoring system might result in a higher predictive value on mortality. The goal of this systematic review is to evaluate the available literature on combinations of biomarkers and clinical scoring systems on 1-month mortality in patients with sepsis in the ED. We performed a systematic search using MEDLINE, EMBASE and Google Scholar. Articles were included if they evaluated at least one biomarker combined with another biomarker or clinical scoring system and reported the prognostic accuracy on 28 or 30 day mortality by area under the curve (AUC) in patients with sepsis. We did not define biomarker cut-off values in advance. We included 18 articles in which a total of 35 combinations of biomarkers and clinical scoring systems were studied, of which 33 unique combinations. In total, seven different clinical scoring systems and 21 different biomarkers were investigated. The combination of procalcitonin (PCT), lactate, interleukin-6 (IL-6) and Simplified Acute Physiology Score-2 (SAPS-2) resulted in the highest AUC on 1-month mortality. The studies we f...Continue Reading

References

Dec 1, 1996·Journal of Clinical Epidemiology·P PeduzziA R Feinstein
Nov 30, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A SpittlerE Roth
Jan 17, 2002·The New England Journal of Medicine·E RiversUNKNOWN Early Goal-Directed Therapy Collaborative Group
Jan 10, 2003·The New England Journal of Medicine·Richard S Hotchkiss, Irene E Karl
Apr 12, 2003·Critical Care Medicine·Mitchell M LevyUNKNOWN SCCM/ESICM/ACCP/ATS/SIS
Dec 18, 2003·Clinical Endocrinology·Susan SamMark E Molitch
Apr 26, 2007·The American Journal of Pathology·Daniel G Remick
Jan 9, 2008·European Journal of Emergency Medicine : Official Journal of the European Society for Emergency Medicine·Alain ViallonJean Claude Bertrand
Jan 17, 2008·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·K KofoedO Andersen
Feb 11, 2010·Critical Care : the Official Journal of the Critical Care Forum·Charalampos Pierrakos, Jean-Louis Vincent
May 25, 2013·The American Journal of Emergency Medicine·Yongzhen ZhaoYumei Jia
Jun 19, 2013·Virulence·Willem Joost WiersingaTom van der Poll
Aug 30, 2013·The New England Journal of Medicine·Derek C Angus, Tom van der Poll
Oct 22, 2013·Critical Care : the Official Journal of the Critical Care Forum·Bo LiuChun-Sheng Li
Jul 26, 2014·The American Journal of Emergency Medicine·Yun-Xia Chen, Chun-Sheng Li
Aug 25, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·Ricardo CarpioGeorg Hess
Sep 21, 2015·The American Journal of Emergency Medicine·Geoffrey E HaydenGreg A Hall
Oct 30, 2015·Critical Care : the Official Journal of the Critical Care Forum·Philipp SchuetzUNKNOWN TRIAGE Study group
Feb 24, 2016·JAMA : the Journal of the American Medical Association·Mervyn SingerDerek C Angus
May 11, 2016·Journal of Thoracic Disease·Panagiotis TsirigotisIoanna Dimopoulou
Jun 9, 2016·The American Journal of Emergency Medicine·Qian ZhangChun-Sheng Li
Jan 24, 2017·JAMA : the Journal of the American Medical Association·Daniel De Backer, Todd Dorman
Aug 11, 2017·Journal of Intensive Care·Ashitha L VijayanManoj G
Aug 23, 2017·Perspectives in Clinical Research·Priya RanganathanRakesh Aggarwal
Jun 6, 2018·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Y van der DoesP P M Rood
Aug 30, 2018·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·Martin SchultzKasper Karmark Iversen
Nov 22, 2018·Journal of Intensive Care·Christopher DuplessisDanielle Clark
Jan 1, 2019·Annals of Internal Medicine·Robert F WolffUNKNOWN PROBAST Group†
Jan 22, 2019·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Keertana BadrinathVijayanarayana Kunhikatta
Jun 7, 2020·Critical Care : the Official Journal of the Critical Care Forum·Charalampos PierrakosJean-Louis Vincent

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