Predicting neuropsychological abnormalities in multiple sclerosis

Journal of the Neurological Sciences
Ralph H B Benedict, R Zivadinov

Abstract

Multiple Sclerosis (MS) is associated with MRI signal alteration and neuropsychological (NP) dysfunction. Screening tools have been developed to identify patients at high risk for these neurological complications of MS. One such measure, the Multiple Sclerosis Neuropsychological Screening Questionnaire (MSNQ), has well-established reliability and predictive validity. In this article, we report on the accumulated findings derived from 162 consecutive research participants and MS clinic attendees. Our data show significant correlation between both patient- and informant-report MSNQ and NP impairment. As shown previously, larger, and more significant correlations are found between informant-report MSNQs than with patient-report MSNQs. In addition, we find that the MSNQ predicts follow-up NP testing 51 weeks after baseline with a similar degree of association. Finally, the MSNQ is correlated with MRI measures of whole-brain lesion burden and atrophy, secondary progressive course, and vocational disability. We conclude that the MSNQ is reliable and valid for detecting neuropsychological and neuropsychiatric complications of MS.

Associated Clinical Trials

Nov 14, 2014·Ralph H.B. BenedictRalph H.B. Benedict

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Citations

May 16, 2007·Journal of Neurology·Ralph H B Benedict, Robert Zivadinov
Jan 13, 2012·Journal of Neurology·Nancy D ChiaravallotiJohn Deluca
Oct 8, 2011·Journal of Clinical and Experimental Neuropsychology·Fernando CáceresUNKNOWN RECONEM Workgroup
Dec 3, 2009·The Clinical Neuropsychologist·Shane StegenRalph H B Benedict
Sep 11, 2010·The Clinical Neuropsychologist·Sarah A MorrowRalph H B Benedict
Mar 14, 2008·The Clinical Neuropsychologist·Amanda Schurle Bruce, Peter A Arnett
Apr 23, 2013·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Emmanuelle DagenaisPierre Duquette
Jun 16, 2012·AJNR. American Journal of Neuroradiology·P L FrancisR I Aviv
Jun 22, 2013·Disability and Rehabilitation·Cynthia A HonanDonald W Hine
Dec 11, 2008·Neuroimaging Clinics of North America·Antonio GiorgioNicola De Stefano
Sep 9, 2015·Multiple Sclerosis and Related Disorders·Victoria M KordovskiRalph H B Benedict
Dec 21, 2012·Journal of Magnetic Resonance Imaging : JMRI·Antonio Giorgio, Nicola De Stefano
Apr 12, 2014·Multiple Sclerosis International·Caroline Jougleux-VieHélène Zéphir
Jan 23, 2015·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Elizabeth A Hubbard, Robert W Motl
Jul 25, 2012·Multiple Sclerosis : Clinical and Laboratory Research·Ralph H B Benedict, Marc K Walton
Dec 8, 2011·Multiple Sclerosis : Clinical and Laboratory Research·Cynthia A HonanJohn D Pollard
Feb 17, 2017·Multiple Sclerosis : Clinical and Laboratory Research·Ralph Hb BenedictUNKNOWN Multiple Sclerosis Outcome Assessments Consortium
Oct 22, 2008·Expert Review of Neurotherapeutics·Maria Pia AmatoEmilio Portaccio
May 21, 2010·Multiple Sclerosis : Clinical and Laboratory Research·J F LoveraD Bourdette
Oct 11, 2008·Multiple Sclerosis : Clinical and Laboratory Research·S VanottiUNKNOWN VANEM Workgroup
Aug 12, 2009·Multiple Sclerosis : Clinical and Laboratory Research·S A MorrowR H B Benedict
Mar 3, 2018·Neuropsychological Rehabilitation·Roshan dasNairGogem Topcu
Feb 26, 2019·Multiple Sclerosis Journal - Experimental, Translational and Clinical·Isaiah KletenikLuis D Medina
Mar 1, 2017·International Journal of MS Care·Sonya KimFrederick W Foley
Apr 3, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Virginia Meca-LallanaFrancisco Pérez-Miralles
Jan 6, 2022·Brain Imaging and Behavior·Tom A FuchsMichael G Dwyer

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