Predicting obstructive coronary artery disease using carotid ultrasound parameters: A nomogram from a large real-world clinical data

European Journal of Clinical Investigation
Na WuLi Zhong

Abstract

Carotid ultrasound is a noninvasive tool for risk assessment of coronary artery disease (CAD). There is no consensus on which carotid ultrasound parameter constitutes the best measurement of atherosclerosis. We investigated which model of carotid ultrasound parameters and clinical risk factors (CRF) has the highest predictive value for CAD. We enrolled 2431 consecutive patients who have suspected CAD and underwent coronary angiography and carotid ultrasound with measurements of carotid intima-media thickness (CIMT), total number of plaques and areas of different types of plaques classified by echogenicity. Total number of plaques demonstrated the highest incremental prediction ability to predict CAD over CRF (area under the curve [AUC] 0.752 vs 0.701, net reclassification index [NRI] = 0.514, P < .001), followed by area of maximum mixed and soft plaques. CIMT had no significant incremental value over CRF (AUC 0.704 vs 0.701, P = .241; NRI = 0.062, P = .168). The model comprising total number of plaques, areas of maximum soft, hard and mixed plaques plus CRF had the highest discriminatory (AUC = 0.757) and reclassification value (NRI = 0.567) for CAD. A nomogram based on this model was developed to predict CAD. For subjects at l...Continue Reading

References

Jul 1, 1992·Stroke; a Journal of Cerebral Circulation·H TanakaK Sueyoshi
May 1, 1986·AJR. American Journal of Roentgenology·E I BluthJ Stewart
Feb 21, 1998·Annals of Internal Medicine·H N HodisS P Azen
Feb 14, 2004·Stroke; a Journal of Cerebral Circulation·J David Spence, Robert A Hegele
Apr 6, 2004·Journal of the American College of Cardiology·Osamu HondaHisao Ogawa
May 11, 2005·American Journal of Hypertension·Vasilios T KotsisNikos A Zakopoulos
Nov 28, 2006·Circulation Journal : Official Journal of the Japanese Circulation Society·Yoshihiro SeoIwao Yamaguchi
Aug 15, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Aloke V FinnRenu Virmani
Jul 22, 2011·The New England Journal of Medicine·Joseph F PolakRalph B D'Agostino
Dec 24, 2011·International Journal of Cardiology·Hyun Woong ParkJang-Ho Bae
Jun 9, 2012·Journal of Clinical Ultrasound : JCU·Evren AldemirEngin Uluc
Aug 23, 2012·JAMA : the Journal of the American Medical Association·Hester M Den RuijterMichiel L Bots
Jul 10, 2013·Journal of cardiovascular ultrasound·Hyun Soo Kim, Kyoung Im Cho

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

Cardiovascular Risk Prediction

Cardiovascular risk prediction models based on classical risk factors identified in epidemiological studies are useful in primary prevention of cardiovascular disease in individuals. Here is the latest research.