Predicting patient-specific rates of bone loss at fracture-prone sites after spinal cord injury

Disability and Rehabilitation
Sylvie CoupaudD B Allan

Abstract

People with spinal cord injury (SCI) experience bone loss and have an elevated rate of fracture in the paralysed limbs. The literature suggests an exponential time course of bone loss after SCI, but true rates may vary between patients. We propose systematic evaluation of bone status in the early stages of SCI to identify fast bone losers. A case series of six patients with complete SCI were scanned using peripheral quantitative computed tomography within 5 weeks and at 4, 8 and 12 months post-injury. Bone mineral density (BMD) and bone mineral content (BMC) were measured at fracture-prone sites in the tibia and femur. Patient-specific-predictions (PSP) of expected rates of bone loss were produced by individualising published model equations according to each patient's measured values at baseline. Wilcoxon Signed-Rank tests were used to identify changes between time-points; chi-squared tests for differences between measured and PSP values. In the lower limbs, mean values decreased significantly between baseline and 8 months post-injury, by 19-31% for trabecular BMD, 21-32% for total BMD, and 9-29% for BMC. Most subjects showed no significant differences between PSP and measured values, but individuals with significantly faster ...Continue Reading

References

Jun 1, 1990·European Journal of Clinical Investigation·F Biering-SørensenO P Schaadt
Jun 1, 1997·Spinal Cord·S M SzollarL J Deftos
Jan 9, 1999·Spinal Cord·G DemirelS Onel
Feb 20, 1999·Archives of Physical Medicine and Rehabilitation·E D de BruinE Stüssi
Jun 23, 2001·Spinal Cord·M G LazoM Muppidi
Jun 1, 1962·American Journal of Surgery·A E COMARRE BORS
Oct 26, 2005·Bone·Cosimo Roberto RussoLuigi Ferrucci
Aug 20, 2008·Spinal Cord·M C AsheA Krassioukov
Dec 18, 2008·The Journal of Spinal Cord Medicine·Douglas E GarlandCharles A Stewart

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Citations

Dec 23, 2015·Topics in Spinal Cord Injury Rehabilitation·Karen L Troy, Leslie R Morse
Feb 8, 2014·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·Magnus K GislasonK Elizabeth Tanner
Mar 31, 2016·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·L M GiangregorioB C Craven

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