PMID: 8584310Oct 1, 1995Paper

Predicting perinatal human immunodeficiency virus infection by antibody patterns

The Pediatric Infectious Disease Journal
D MoodleyHoosen Coovadia

Abstract

The evolution of human immunodeficiency virus type 1 (HIV-1) antibody titers determined by enzyme-linked immunosorbent assay between birth and 18 months of age was investigated in 118 babies born to HIV-1-seropositive South African mothers. By 18 months 41 (34.7%) children were diagnosed as HIV-1-infected by standard criteria. All 77 uninfected babies cleared maternal antibodies by 15 months; 94.5% of these babies seroreverted by 12 months. By 9 months of age a significant difference (P < 0.05) was noted between antibody decay rates in infected and uninfected children. Of the children subsequently shown to be uninfected, 95.8% demonstrated > or = 50% decay in antibody titers between 6 and 9 months; only 1 in the infected group showed a similar pattern (sensitivity, 97.8%; specificity, 93.8%). The approach of assessing the progression of antibody decay in infected and uninfected babies makes it a feasible and useful tool for estimating vertical transmission rates and diagnosis of perinatal HIV-1 infection earlier than standard practice.

Citations

Aug 2, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mavel GutierrezGwendolyn B Scott
Apr 15, 1996·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·L KuhnZ A Stein
Oct 31, 2006·The Pediatric Infectious Disease Journal·Amy Sarah GinsburgCatherine M Wilfert
Dec 13, 2005·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Irene N KoulinskaMax Essex
May 30, 2009·The Pediatric Infectious Disease Journal·Jennifer S ReadGwendolyn Scott
Sep 1, 2012·The Pediatric Infectious Disease Journal·Benjamin H ChiJeffrey S A Stringer
Mar 29, 2011·BMC Pediatrics·Elizabeth W Kimani-MurageKathleen Kahn
Jan 25, 2014·The Lancet Infectious Diseases·Martina PenazzatoDiana M Gibb
Jul 8, 2011·Bulletin of the World Health Organization·Nicolas GrundmannCatherine Wilfert
Nov 3, 2005·Tropical Medicine & International Health : TM & IH·Gayle G ShermanStephanie A Jones
Dec 6, 2008·Tropical Medicine & International Health : TM & IH·Peter IliffJean Humphrey
Apr 24, 2014·Tropical Medicine & International Health : TM & IH·Madalitso MaliwichiEric D McCollum
Jan 16, 1998·Obstetrics and Gynecology Clinics of North America·A J Melvin, L M Frenkel
Aug 29, 2012·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Ann M BuchananHugh Reyburn
Sep 14, 2007·American Journal of Obstetrics and Gynecology·Tracy L CreekNathan Shaffer
Sep 16, 2016·Maternal and Child Health Journal·Emily R SmithAnnelies Van Rie
Sep 8, 2017·Expert Opinion on Pharmacotherapy·Jean-Christophe BeghinDimitri Van der Linden
Sep 22, 2018·The Pediatric Infectious Disease Journal·Sunsanee ChatpornvoraruxKulkanya Chokephaibulkit
Nov 1, 2016·The Pediatric Infectious Disease Journal·Emily R SmithAnnelies Van Rie
Jan 12, 2005·Clinical and Diagnostic Laboratory Immunology·A J De BaetsK Fransen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.