Predicting Plasma Free Hemoglobin Levels in Patients Due to Medical Device-Related Hemolysis

ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs
David M SaylorRichard A Malinauskas

Abstract

Blood passage through medical devices can cause hemolysis and increased levels of plasma free hemoglobin (pfH) that may lead to adverse effects such as vasoconstriction and renal tubule injury. Although the hemolytic potential of devices is typically characterized in vitro using animal blood, the results can be impacted by various blood parameters, such as donor species. Moreover, it is unclear how to relate measured in vitro hemolysis levels to clinical performance because pfH accumulation in vivo depends on both hemolysis rate and availability of plasma haptoglobin (Hpt) that can bind and safely eliminate pfH. To help to address these uncertainties, we developed a biokinetic model linking in vivo hemolysis rates to time-dependent pfH and Hpt concentrations. The model was initially parameterized using studies that characterized baseline levels and evolution of pfH and Hpt after introduction of excess pfH in humans. With the biokinetic parameters specified, the model was applied to predict hemolysis rates in three patient groups undergoing cardiopulmonary bypass surgery. The congruity of the model with these clinical data suggests that it can infer in vivo hemolysis rates and provide insight into pfH levels that may cause conce...Continue Reading

References

Jan 1, 1990·Archives of Disease in Childhood·I HudsonT Turner
Jun 1, 1971·The Journal of Experimental Medicine·N R PimstoneR Schmid
Jul 1, 1967·American Journal of Surgery·E F BernsteinK H Keller
Jan 1, 1984·American Journal of Perinatology·D C AlversonW Berman
Jul 3, 1998·Artificial Organs·Y Nosé
Feb 24, 2001·Nature·M KristiansenS K Moestrup
Aug 22, 2002·Congestive Heart Failure·D BS DykeK D Aaronson
Apr 7, 2005·JAMA : the Journal of the American Medical Association·Russell P RotherMark T Gladwin
Jan 5, 2006·Circulation·J Timothy BaldwinTracey R Hoke
Mar 1, 2006·BMC Pediatrics·Ann RaesJohan Vande Walle
Nov 13, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Rasheed GbadegesinJen-Jar Lin
Feb 26, 2010·Kidney International·Iris C Vermeulen WindsantMichael J Jacobs
Jul 31, 2012·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Marcus CarlssonHakan Arheden
Jun 20, 2013·Oxidative Medicine and Cellular Longevity·Jens Haugbølle ThomsenSøren K Moestrup
Aug 24, 2013·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Palak ShahFrancis D Pagani
Jan 8, 2014·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Lara S MamikonianJennifer L Turi
Jan 15, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jennifer A CowgerFrancis D Pagani
Apr 12, 2014·Frontiers in Pediatrics·Oswin Grollmuss, Patricia Gonzalez
Apr 16, 2014·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Scott A SimpsonMias Pretorius
May 9, 2014·Interactive Cardiovascular and Thoracic Surgery·Zaccaria RicciPaola Cogo
Apr 9, 2016·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Joseph W RossanoJames K Kirklin
May 18, 2016·Artificial Organs·Rohan J KalathiyaRyan J Tedford
Oct 25, 2016·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Michael V GavalasPaolo C Colombo
Jan 24, 2017·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Richard A MalinauskasBrent A Craven
Mar 23, 2017·Physiological Reports·Giles N CattermoleTimothy H Rainer
Jul 15, 2017·Journal of the American College of Cardiology·David M SmadjaAlain Carpentier
Jul 27, 2017·Artificial Organs·Chris H H ChanCatherine A Thornton

❮ Previous
Next ❯

Citations

Jul 28, 2020·PLoS Computational Biology·William Davis HaseldenPatrick J Drew
Sep 13, 2019·Journal of Inorganic Biochemistry·Sophia Sarpong-Kumankomah, Jürgen Gailer
May 15, 2021·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Kai von Petersdorff-Campen, Marianne Schmid Daners

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.