Predicting pneumonitis risk: a dosimetric alternative to mean lung dose.

International Journal of Radiation Oncology, Biology, Physics
Susan L TuckerZhongxing Liao

Abstract

To determine whether the association between mean lung dose (MLD) and risk of severe (grade ≥3) radiation pneumonitis (RP) depends on the dose distribution pattern to normal lung among patients receiving 3-dimensional conformal radiation therapy for non-small-cell lung cancer. Three cohorts treated with different beam arrangements were identified. One cohort (2-field boost [2FB]) received 2 parallel-opposed (anteroposterior-posteroanterior) fields per fraction initially, followed by a sequential boost delivered using 2 oblique beams. The other 2 cohorts received 3 or 4 straight fields (3FS and 4FS, respectively), ie, all fields were irradiated every day. The incidence of severe RP was plotted against MLD in each cohort, and data were analyzed using the Lyman-Kutcher-Burman (LKB) model. The incidence of grade ≥3 RP rose more steeply as a function of MLD in the 2FB cohort (N=120) than in the 4FS cohort (N=138), with an intermediate slope for the 3FS group (N=99). The estimated volume parameter from the LKB model was n=0.41 (95% confidence interval, 0.15-1.0) and led to a significant improvement in fit (P=.05) compared to a fit with volume parameter fixed at n=1 (the MLD model). Unlike the MLD model, the LKB model with n=0.41 prov...Continue Reading

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Jul 6, 2010·International Journal of Radiation Oncology, Biology, Physics·Susan L TuckerJames D Cox
Mar 8, 2011·International Journal of Radiation Oncology, Biology, Physics·Susan L TuckerLei Dong
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Jul 12, 2011·International Journal of Radiation Oncology, Biology, Physics·Yevgeniy VinogradskiyMary K Martel
Feb 22, 2012·International Journal of Radiation Oncology, Biology, Physics·Susan L TuckerRadhe Mohan

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Citations

Mar 17, 2015·Seminars in Radiation Oncology·Feng-Ming Spring Kong, Shulian Wang
Apr 30, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Alize E H ScheenstraJan-Jakob Sonke
Apr 14, 2015·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Thomas HerrmannSteffen Appold
May 10, 2016·Practical Radiation Oncology·Eileen M HarderRoy H Decker
May 17, 2017·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·Dilruba OkumusDeniz Sigirli
Jan 3, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Zhongxing LiaoRadhe Mohan
Aug 21, 2019·The British Journal of Radiology·Olsi Gjyshi, Zhongxing Liao
May 29, 2018·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Jens FleckensteinAnna Simeonova-Chergou
Oct 31, 2019·Expert Review of Anticancer Therapy·Michael T MilanoFeng-Ming Spring Kong
May 11, 2021·Technology in Cancer Research & Treatment·Melek YakarOzer Celik

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