Predicting post-external beam radiation therapy PSA relapse of prostate cancer using pretreatment MRI.

International Journal of Radiation Oncology, Biology, Physics
Michael H FuchsjägerHedvig Hricak

Abstract

To investigate whether pretreatment endorectal magnetic resonance imaging (MRI) findings can predict biochemical relapse in patients with clinically localized prostate cancer treated with external beam radiation therapy (EBRT). Between January 2000 and January 2002, 224 patients (median age, 69 years; age range, 45-82 years) with biopsy-proven prostate cancer underwent endorectal MRI before high-dose (≥81Gy) EBRT. The value of multiple clinical and MRI variables in predicting prostate-specific antigen (PSA) relapse at 5 years was determined by use of univariate and multivariate stepwise Cox regression. Clinical variables included pretreatment PSA, clinical T stage, Gleason score, use of neoadjuvant hormonal therapy, and radiation dose. Magnetic resonance imaging variables, derived from retrospective consensus readings by two radiologists, were used to measure intraprostatic and extraprostatic tumor burden. After a median follow-up of 67 months, PSA relapse developed in 37 patients (16.5%). The significant predictors of PSA relapse on univariate analysis were pretreatment PSA, clinical T stage, and multiple MRI variables, including MRI TN stage score; extracapsular extension (ECE) status; number of sextants involved by ECE, all ...Continue Reading

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Citations

Nov 3, 2012·The Lancet Oncology·Hashim Uddin AhmedMark Emberton
Dec 1, 2010·Nature Reviews. Clinical Oncology·Markos KaravitakisMathias H Winkler
Oct 21, 2015·Clinical Oncology : a Journal of the Royal College of Radiologists·J UzanI Syndikus
Apr 2, 2013·Brachytherapy·Patrick W McLaughlin, Vrinda Narayana
Mar 10, 2018·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Sung Yoon ParkYoung Taik Oh

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