Predicting Postoperative Mortality After Metastatic Intraspinal Neoplasm Excision: Development of a Machine-Learning Approach.

World Neurosurgery
Kevin J DiSilvestroAlan H Daniels

Abstract

Mortality following surgical resection of spinal tumors is a devastating outcome. Naïve Bayes machine learning algorithms may be leveraged in surgical planning to predict mortality. In this investigation, we use a Naïve Bayes classification algorithm to predict mortality following spinal tumor excision within 30 days of surgery. Patients who underwent laminectomies between 2006 and 2018 for excisions of intraspinal neoplasms were selected from the National Surgical Quality Initiative Program. Naïve Bayes classifier analysis was conducted in Python. The area under the receiver operating curve (AUC) was calculated to evaluate the classifier's ability to predict mortality within 30 days of surgery. Multivariable logistic regression analysis was performed in R to identify risk factors for 30-day postoperative mortality. In total, 2094 spine tumor surgery patients were included in the study. The 30-day mortality rate was 5.16%. The classifier yielded an AUC of 0.898, which exceeds the predictive capacity of the National Surgical Quality Initiative Program mortality probability calculator's AUC of 0.722 (P < 0.0001). The multivariable regression indicated that smoking history, chronic obstructive pulmonary disease, disseminated cance...Continue Reading

References

Feb 9, 2006·Neurosurgical Focus·W B Jacobs, R G Perrin
May 9, 2007·Journal of Nutritional Science and Vitaminology·Ikuko GomHisataka Moriwaki
Sep 22, 2009·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Henry A PittSean J Mulvihill
Jan 19, 2010·Bioinformatics·Vanathi GopalakrishnanGregory F Cooper
Jan 1, 2010·Frontiers in Psychology·Chris F Westbury
Apr 25, 2012·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Matthias PumbergerStavros G Memtsoudis
Nov 2, 2014·Frontiers in Computational Neuroscience·Concha Bielza, Pedro Larrañaga
Nov 5, 2014·PloS One·Mats Gunnar AnderssonAgnès Leblond
Mar 1, 2016·World Journal of Orthopedics·Mert CiftdemirErol Yalniz
Mar 18, 2017·Circulation·Tetsuro ShimuraUNKNOWN OCEAN-TAVI Investigators
Jul 12, 2017·Statistics in Biosciences·Peizhou LiaoTianwei Yu
Sep 7, 2017·NeuroImage·Marlis Ontivero-OrtegaMitchell Valdes-Sosa
Apr 3, 2018·World Neurosurgery·Christopher A SarkissJohn M Caridi
Sep 24, 2018·The Journal of Arthroplasty·Sergio M NavarroPrem N Ramkumar
Nov 25, 2018·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Heather VanderMeulen, Michelle Sholzberg
Dec 14, 2018·Journal of Neurosurgery. Spine·Saisanjana KalagaraAlan H Daniels
Mar 21, 2019·BMC Medical Research Methodology·Jenni A M Sidey-Gibbons, Chris J Sidey-Gibbons
Jul 13, 2019·Annals of Translational Medicine·Alexander T YahandaAdam M Wegner
Aug 1, 2019·Future Healthcare Journal·Thomas Davenport, Ravi Kalakota
Aug 30, 2019·JOR Spine·Fabio GalbuseraTito Bassani
Aug 31, 2019·Scientific Reports·Li ShenWeiva Sieh
Oct 19, 2019·Annals of Translational Medicine·Azeem Tariq Malik, Safdar N Khan
Jan 1, 2020·BMC Medical Research Methodology·Shannon WongvibulsinScott L Zeger

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Citations

Oct 12, 2021·Global Spine Journal·GuanRui RenXiaoTao Wu

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