Dec 7, 2018

Predicting Progression to Mild Cognitive Impairment

Annals of Neurology
Ronald C PetersenClifford R Jack

Abstract

Despite much attention to the use of biomarkers for predicting Alzheimer disease, little information is available at the individual level. We used the population-based Mayo Clinic Study of Aging to estimate absolute risk of cognitive impairment by biomarker group. Risk increased with age and any biomarker abnormality. For example, a 75-year-old with abnormal amyloid and cortical thinning biomarkers has about a 20% chance of cognitive impairment by age 80 years, whereas with normal biomarkers the chance is <10%. Persons with only one abnormal biomarker had similar intermediate risks. ANN NEUROL 2019;85:155-160.

  • References20
  • Citations5

Citations

Mentioned in this Paper

Biological Markers
APP protein, human
Senility
Alzheimer's Disease
Persons
Bikinia le-testui
Longitudinal Survey
Structure of Cortex of Kidney
Amyloid Deposition
Amyloid

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