Predicting protein subcellular location by fusing multiple classifiers

Journal of Cellular Biochemistry
Kuo-Chen Chou, Hong-Bin Shen

Abstract

One of the fundamental goals in cell biology and proteomics is to identify the functions of proteins in the context of compartments that organize them in the cellular environment. Knowledge of subcellular locations of proteins can provide key hints for revealing their functions and understanding how they interact with each other in cellular networking. Unfortunately, it is both time-consuming and expensive to determine the localization of an uncharacterized protein in a living cell purely based on experiments. With the avalanche of newly found protein sequences emerging in the post genomic era, we are facing a critical challenge, that is, how to develop an automated method to fast and reliably identify their subcellular locations so as to be able to timely use them for basic research and drug discovery. In view of this, an ensemble classifier was developed by the approach of fusing many basic individual classifiers through a voting system. Each of these basic classifiers was trained in a different dimension of the amphiphilic pseudo amino acid composition (Chou [2005] Bioinformatics 21: 10-19). As a demonstration, predictions were performed with the fusion classifier for proteins among the following 14 localizations: (1) cell w...Continue Reading

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Citations

Jul 27, 2010·Interdisciplinary Sciences, Computational Life Sciences·Xuan-Min GuangMeng-Long Li
Jan 26, 2016·Journal of Theoretical Biology·Jianhua JiaKuo-Chen Chou
Jun 4, 2011·Journal of Theoretical Biology·Ya-Nan ZhangHong-Bin Shen
Dec 21, 2010·Journal of Theoretical Biology·Kuo-Chen Chou
Sep 10, 2010·Journal of Theoretical Biology·Xuanmin GuangMenglong Li
Dec 8, 2009·Journal of Theoretical Biology·Maryam EsmaeiliSasan Mohsenzadeh
Feb 24, 2009·Medical Image Analysis·Jong-Hwan LeeSeung-Schik Yoo
Nov 15, 2008·Analytical Biochemistry·Hong-Bin Shen, Kuo-Chen Chou
Apr 22, 2008·Journal of Theoretical Biology·Chao ChenPei-Xiang Cai
Aug 19, 2007·Analytical Biochemistry·Kuo-Chen Chou, Hong-Bin Shen
Jun 19, 2007·Journal of Theoretical Biology·Lukasz A KurganJishou Ruan
Apr 28, 2010·IEEE/ACM Transactions on Computational Biology and Bioinformatics·Qian XuQiang Yang
Sep 19, 2012·IEEE Transactions on Nanobioscience·Guo-Zheng LiRui-Wei Zhao
Nov 3, 2010·Journal of Theoretical Biology·Pooya ZakeriMehdi Sadeghi
Jul 11, 2007·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Neta Regev-Rudzki, Ophry Pines
Feb 26, 2008·Proteomics·Humberto González-DíazEugenio Uriarte
Nov 28, 2008·Journal of Computational Chemistry·Xuan XiaoKuo-Chen Chou
Oct 7, 2009·The Protein Journal·Lin ZhuHong-Bin Shen
Aug 21, 2007·Expert Review of Proteomics·Hong-Bin ShenKuo-Chen Chou

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