Abstract
Radiotherapy (RT), the main treatment for patients with head and neck cancer, can lead to dental complications. We identified 244 patients with squamous cell carcinoma of the tonsil treated with RT from 2004 to 2013. For each patient, we contoured the 10 tooth-bearing regions and calculated the radiation dose (gray, Gy) to each region. From this data set, we built two predictive models to determine the expected maximum radiation dose, one for the non-molar regions and another for the molar regions. For the non-molars, the final model included location, T-classification, and overall stage, with a median absolute prediction error of 7.0 Gy. For the molars, the final model included location, T-classification, overall stage, and treatment year, with a median absolute error of 6.0 Gy. Our current model offers a good estimation of the maximum radiation dose delivered to different regions of the jaw; future work will independently validate these models.
References
Dec 17, 2005·Head & Neck·Nancy LeeK S Clifford Chao
Mar 5, 2010·International Journal of Radiation Oncology, Biology, Physics·Søren M BentzenEllen D Yorke
Mar 5, 2010·International Journal of Radiation Oncology, Biology, Physics·Joseph O DeasyAvraham Eisbruch
Mar 5, 2010·International Journal of Radiation Oncology, Biology, Physics·Tiziana RancatiAvraham Eisbruch
Mar 5, 2010·International Journal of Radiation Oncology, Biology, Physics·Maria Werner-WasikLawrence B Marks
Dec 21, 2010·International Journal of Radiation Oncology, Biology, Physics·Jeremy SettonNancy Y Lee
Feb 18, 2011·Cancer Treatment Reviews·Silke Tribius, Corinna Bergelt
Jun 7, 2011·International Journal of Radiation Oncology, Biology, Physics·Vitali MoiseenkoAnna Thompson
Aug 23, 2011·Practical Radiation Oncology·Mary P WalkerKaren B Williams
Feb 4, 2012·International Journal of Radiation Oncology, Biology, Physics·Allen M ChenJames A Purdy
Jul 10, 2012·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Heidi J HansenCherry L Estilo
Sep 4, 2013·Acta Oncologica·Ivo BeetzJohannes A Langendijk
Jul 15, 2015·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Karina Morais-FariaAlan Roger Santos-Silva
Aug 13, 2015·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Gabriela StuderChristoph Glanzmann
Nov 17, 2015·Expert Review of Anticancer Therapy·Lucas Castro MendezGustavo Nader Marta
Dec 19, 2015·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Sun-Yung BakSteve P Lee
Oct 19, 2016·Head & Neck·Cláudia Joffily ParahybaEduardo Rodrigues Fregnani
Sep 9, 2016·Radiation Oncology·Eduardo Rodrigues FregnaniThais B Brandão
Oct 22, 2016·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Adepitan A OwoshoCherry L Estilo
Dec 28, 2016·Oral Oncology·Adepitan A OwoshoCherry L Estilo