Predicting recurrence after unprovoked venous thromboembolism: prospective validation of the updated Vienna Prediction Model.

Blood
Tobias TritschlerD Aujesky

Abstract

The updated Vienna Prediction Model for estimating recurrence risk after an unprovoked venous thromboembolism (VTE) has been developed to identify individuals at low risk for VTE recurrence in whom anticoagulation (AC) therapy may be stopped after 3 months. We externally validated the accuracy of the model to predict recurrent VTE in a prospective multicenter cohort of 156 patients aged ≥65 years with acute symptomatic unprovoked VTE who had received 3 to 12 months of AC. Patients with a predicted 12-month risk within the lowest quartile based on the updated Vienna Prediction Model were classified as low risk. The risk of recurrent VTE did not differ between low- vs higher-risk patients at 12 months (13% vs 10%; P = .77) and 24 months (15% vs 17%; P = 1.0). The area under the receiver operating characteristic curve for predicting VTE recurrence was 0.39 (95% confidence interval [CI], 0.25-0.52) at 12 months and 0.43 (95% CI, 0.31-0.54) at 24 months. In conclusion, in elderly patients with unprovoked VTE who have stopped AC, the updated Vienna Prediction Model does not discriminate between patients who develop recurrent VTE and those who do not. This study was registered at www.clinicaltrials.gov as #NCT00973596.

Associated Clinical Trials

Sep 9, 2009·Drahomir Aujesky

References

Jul 21, 2001·The New England Journal of Medicine·G AgnelliUNKNOWN Warfarin Optimal Duration Italian Trial Investigators
Aug 28, 2003·JAMA : the Journal of the American Medical Association·Sabine EichingerPaul A Kyrle
Jul 13, 2005·Archives of Internal Medicine·Marieke TornFrits R Rosendaal
Aug 30, 2008·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Marc A RodgerMichael J Kovacs
Feb 26, 2011·BMJ : British Medical Journal·James DouketisAlfonso Iorio
Jan 30, 2013·Journal of Thrombosis and Thrombolysis·Marie MéanDrahomir Aujesky
Jan 5, 2014·Journal of the American Heart Association·Sabine EichingerPaul A Kyrle
Feb 25, 2014·The American Journal of Medicine·Frederick A SpencerRobert J Goldberg

❮ Previous
Next ❯

Citations

Apr 24, 2016·The Veterinary Journal·Unity JefferyDana LeVine
Mar 23, 2017·European Journal of Haematology·Chong Chyn ChuaPrahlad Ho
Jan 8, 2017·Arteriosclerosis, Thrombosis, and Vascular Biology·Michal ZabczykAnetta Undas
Apr 6, 2019·Vascular Medicine·Maya Serhal, Geoffrey D Barnes
Jun 21, 2019·Journal of Thrombosis and Haemostasis : JTH·Willem M LijferingSuzanne C Cannegieter
Jun 13, 2019·Journal of Thrombosis and Haemostasis : JTH·Jasmijn F TimpSuzanne C Cannegieter
Aug 2, 2017·Journal of Thrombosis and Haemostasis : JTH·A TosettoG Palareti
Feb 15, 2019·Clinical Epigenetics·Xiao WangBengt Zöller
May 3, 2020·International Journal of Laboratory Hematology·Charlotte RobertsonHenry Watson
Mar 15, 2020·International Journal of Molecular Sciences·Larisa AnghelCristian Stătescu
Dec 31, 2020·TH Open : Companion Journal to Thrombosis and Haemostasis·Jeffrey I WeitzPeter Verhamme
Jul 1, 2020·International Journal of Medical Informatics·T D MartinsR Maciel Filho
Aug 21, 2021·TH Open : Companion Journal to Thrombosis and Haemostasis·S SoudetM A Sevestre Pietri

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.