Predicting residual neck disease in patients with oropharyngeal squamous cell carcinoma treated with radiation therapy: utility of p16 status

Archives of Otolaryngology--head & Neck Surgery
David C ShonkaMark J Jameson

Abstract

To identify factors that predict complete response of cervical nodal disease to radiation therapy (RT) in patients with oropharyngeal squamous cell carcinoma (OP-SCCA). Histologic analysis of prospectively collected specimens and retrospective medical chart review. Tertiary referral center. Sixty-nine patients with OP-SCCA treated from January 1, 2002, through June 1, 2008. Definitive RT, with or without chemotherapy and with or without neck dissection (ND). Presence of a viable tumor in post-RT ND specimen. Tissue specimens from 69 patients with OP-SCCA treated primarily with RT, with or without chemotherapy, were evaluated. Of these, 47 (68.1%) were strongly and diffusely positive for p16 expression by immunohistochemical analysis, signifying human papillomavirus positivity. Patients with p16-positive and p16-negative tumors (hereinafter, p16+ and p16-, respectively) had similarly sized primary tumors on presentation, but p16+ primary tumors were associated with more advanced neck disease (nodal stages N2c-N3; 31.9% vs 4.5% for p16- tumors) and more contralateral nodes (27.7% vs 4.5% for p16- tumors). Forty-seven patients (59.0%) underwent planned posttreatment ND (a total of 55 NDs). The NDs performed for p16- tumors were si...Continue Reading

Citations

Mar 10, 2012·Annals of Surgical Oncology·Juliette ThariatXavier Dufour
Aug 26, 2014·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Raul PelliniGiuseppe Spriano
Jan 10, 2014·Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'oto-rhino-laryngologie Et De Chirurgie Cervico-faciale·Brittany R BarberHadi Seikaly
Jul 20, 2010·Wiener medizinische Wochenschrift·Jan KlozarEva Hamšíková
Jun 11, 2015·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·R MaquieiraMartina A Broglie
Jun 28, 2014·International Journal of Oncology·Masahiro HasegawaMikio Suzuki

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