PMID: 11605182Oct 18, 2001Paper

Predicting response to paclitaxel/carboplatin-based therapy in non-small cell lung cancer

Seminars in Oncology
Rafael Rosell, Enriqueta Felip

Abstract

Non-small cell lung cancer (NSCLC) is a systemic illness. The majority of newly diagnosed patients depend on systemic chemotherapy to improve outcome. Among the new chemotherapeutic agents recently tested, paclitaxel (Taxol; Bristol-Myers Squibb Company, Princeton, NJ) has shown convincing single-agent activity in advanced NSCLC. The two initial phase II studies using paclitaxel alone showed a 1-year survival rate of 40%, comparable to that seen with combination regimens. Paclitaxel/carboplatin is one of several standard regimens for patients with stage IIIB to IV disease. It is as effective as any other new agent/platinum combination studied to date; it is easy to administer and well tolerated. Identification of the molecular and genetic events involved in each step of tumor progression seems to be crucial both to understanding lung cancer and for the development of new pharmacologic compounds that target specific cellular processes affecting growth and proliferation. An innovative strategy is to combine established chemotherapy with these new compounds. Resistance to available chemotherapy drugs is the major obstacle to effective chemotherapy. Genetic abnormalities could play a role in outlining some patterns of chemoresistan...Continue Reading

Citations

Jun 11, 2002·Current Opinion in Pulmonary Medicine·Eric B Haura
Jul 31, 2012·Pharmacogenomics·Elisa GiovannettiGodefridus J Peters
Aug 13, 2013·Expert Opinion on Medical Diagnostics·Eric S Kim, Kishan J Pandya
Oct 10, 2002·British Journal of Cancer·J Cosaert, E Quoix
Mar 5, 2003·Pharmacological Reviews·Romano DanesiMario Del Tacca
Mar 24, 2012·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·William SterlacciAlexandar Tzankov
Mar 25, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kyu-Sik KimKyung-Ok Park
Feb 3, 2021·Photodiagnosis and Photodynamic Therapy·Haixiu MaLing Kang
Apr 8, 2021·Cell Death Discovery·Onsurang WattanathamsanVarisa Pongrakhananon

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