Predicting risk for childhood asthma by pre-pregnancy, perinatal, and postnatal factors

Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
Hui-Ju WenYue Leon Guo

Abstract

Symptoms of atopic disease start early in human life. Predicting risk for childhood asthma by early-life exposure would contribute to disease prevention. A birth cohort study was conducted to investigate early-life risk factors for childhood asthma and to develop a predictive model for the development of asthma. National representative samples of newborn babies were obtained by multistage stratified systematic sampling from the 2005 Taiwan Birth Registry. Information on potential risk factors and children's health was collected by home interview when babies were 6 months old and 5 yr old, respectively. Backward stepwise regression analysis was used to identify the risk factors of childhood asthma for predictive models that were used to calculate the probability of childhood asthma. A total of 19,192 children completed the study satisfactorily. Physician-diagnosed asthma was reported in 6.6% of 5-yr-old children. Pre-pregnancy factors (parental atopy and socioeconomic status), perinatal factors (place of residence, exposure to indoor mold and painting/renovations during pregnancy), and postnatal factors (maternal postpartum depression and the presence of atopic dermatitis before 6 months of age) were chosen for the predictive mo...Continue Reading

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Citations

Nov 20, 2015·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Marco CaminatiGianenrico Senna
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Jan 14, 2018·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C FlaniganB I Nwaru
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Jul 16, 2021·International Journal of Epidemiology·Ling-Yin ChangTung-Liang Chiang
Aug 14, 2021·Journal of the American Academy of Dermatology·Hongmin LiCheng Tan

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