Predicting risk of osteoporotic fracture in men and women in England and Wales: prospective derivation and validation of QFractureScores.

BMJ : British Medical Journal
Julia Hippisley-Cox, Carol Coupland

Abstract

To develop and validate two new fracture risk algorithms (QFractureScores) for estimating the individual risk of osteoporotic fracture or hip fracture over 10 years. Prospective open cohort study with routinely collected data from 357 general practices to develop the scores and from 178 practices to validate the scores. General practices in England and Wales. 1 183 663 women and 1 174 232 men aged 30-85 in the derivation cohort, who contributed 7 898 208 and 8 049 306 person years of observation, respectively. There were 24 350 incident diagnoses of osteoporotic fracture in women and 7934 in men, and 9302 incident diagnoses of hip fracture in women and 5424 in men. First (incident) diagnosis of osteoporotic fracture (vertebral, distal radius, or hip) and incident hip fracture recorded in general practice records. Use of hormone replacement therapy (HRT), age, body mass index (BMI), smoking status, recorded alcohol use, parental history of osteoporosis, rheumatoid arthritis, cardiovascular disease, type 2 diabetes, asthma, tricyclic antidepressants, corticosteroids, history of falls, menopausal symptoms, chronic liver disease, gastrointestinal malabsorption, and other endocrine disorders were significantly and independently asso...Continue Reading

References

Dec 3, 1992·The New England Journal of Medicine·M C ChapuyP J Meunier
Sep 1, 1993·American Journal of Public Health·K A HollenbachT Holbrook
Apr 6, 1999·The American Journal of Medicine·J CornuzG A Colditz
Dec 22, 1999·International Journal of Epidemiology·P RoystonW Sauerbrei
Jun 7, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T P Van StaaC Cooper
Jun 22, 2000·The New England Journal of Medicine·K Benson, A J Hartz
Oct 18, 2000·The Cochrane Database of Systematic Reviews·M J ParkerW J Gillespie
Feb 15, 2001·The New England Journal of Medicine·M R McClungUNKNOWN Hip Intervention Program Study Group
Mar 10, 2001·Stroke; a Journal of Cerebral Circulation·J KanisO Johnell
Mar 30, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T P van StaaC Cooper
Jun 2, 2001·The New England Journal of Medicine·K L Sauder
Jun 26, 2001·British Journal of Clinical Pharmacology·T P van StaaH G Leufkens
Aug 31, 2001·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·D M BlackO Johnell
Jul 2, 2002·Psychological Methods·Joseph L Schafer, John W Graham
Jul 19, 2002·JAMA : the Journal of the American Medical Association·Jacques E RossouwUNKNOWN Writing Group for the Women's Health Initiative Investigators
Feb 19, 2003·Journal of Clinical Epidemiology·Taane G Clark, Douglas G Altman
Jul 2, 2003·American Journal of Epidemiology·Richard HubbardAnne Tattersfield
Dec 4, 2003·Journal of Internal Medicine·P Vestergaard, L Mosekilde
Feb 26, 2004·Statistics in Medicine·Patrick Royston, Willi Sauerbrei
May 13, 2004·JAMA : the Journal of the American Medical Association·Emily BanksUNKNOWN Million Women Study Collaborators
Jun 4, 2004·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J A KanisA Tenenhouse
Sep 30, 2004·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·John A KanisAlan Tenenhouse
Jan 27, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J A KanisB Jönsson
Feb 25, 2005·The Journal of Clinical Endocrinology and Metabolism·Stacey A WainwrightUNKNOWN Study of Osteoporotic Fractures Research Group
Jun 2, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·C De LaetA Tenenhouse
Sep 19, 2006·Journal of Clinical Epidemiology·Karel G M MoonsFrank E Harrell
Oct 18, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Eugene V McCloskeyJohn A Kanis
Dec 28, 2006·JAMA : the Journal of the American Medical Association·Yu-Xiao YangDavid C Metz
Feb 3, 2007·The British Journal of Psychiatry : the Journal of Mental Science·Louise HowardMorven Leese
Aug 11, 2007·Journal of Clinical Epidemiology·Ewout W Steyerberg, Mirjam van Veen
Nov 29, 2007·JAMA : the Journal of the American Medical Association·John RobbinsJane Cauley
Dec 11, 2007·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A Moayyeri
Dec 13, 2007·JAMA : the Journal of the American Medical Association·Carole WilliJacques Cornuz
Feb 13, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J A KanisUNKNOWN European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO)
Feb 23, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·B Dawson-HughesUNKNOWN National Osteoporosis Foundation Guide Committee
Feb 23, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J A KanisE McCloskey
Mar 6, 2008·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Tim A HoltAzeem Majeed
Mar 6, 2008·JAMA : the Journal of the American Medical Association·Gerardo HeissUNKNOWN WHI Investigators
Apr 19, 2008·The New England Journal of Medicine·Rebecca D KushC David Hardison
Jun 25, 2008·BMJ : British Medical Journal·Julia Hippisley-CoxPeter Brindle
Aug 30, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J A KanisUNKNOWN National Osteoporosis Guideline Group

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Citations

Sep 5, 2012·Diabetologia·H M ColhounUNKNOWN Scottish Diabetes Research Network Epidemiology Group
Aug 5, 2010·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·K H RubinK Brixen
Jan 15, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·C H BowA W C Kung
Mar 17, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M FrostK Brixen
May 13, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·E Y N CheungA Kung
Jul 23, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J A KanisUNKNOWN Task Force of the FRAX Initiative
Nov 29, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J A KanisE McCloskey
Feb 22, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·V YoonK Sakhaee
May 24, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J Sanfélix-GenovésC Baixauli
Oct 20, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J A KanisUNKNOWN Scientific Advisory Board of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCE
Apr 19, 2013·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M KauppiA Jula
Nov 8, 2011·Calcified Tissue International·John A KanisWilliam D Leslie
Jul 12, 2012·Calcified Tissue International·Ernest K PokuJeff D Newman
Mar 22, 2013·Calcified Tissue International·Mickael HiligsmannJean-Yves Reginster
Feb 18, 2011·European Journal of Clinical Pharmacology·Linda BrewerAlan Moore
Mar 28, 2012·European Journal of Epidemiology·Lili MaFernando Rivadeneira
Oct 13, 2012·Archives of Osteoporosis·Sansin TuzunUNKNOWN Turkish Osteoporosis Society
Nov 30, 2010·Current Osteoporosis Reports·Robert A Adler
Apr 21, 2011·Current Osteoporosis Reports·E Michael Lewiecki
Jan 26, 2012·Current Osteoporosis Reports·Sanford Baim, William D Leslie
Jun 13, 2012·Current Osteoporosis Reports·Gary S Collins, Karl Michaëlsson
Sep 25, 2012·Current Osteoporosis Reports·Monique J Brown, Briana Mezuk
Jan 6, 2012·BMJ : British Medical Journal·Julia Hippisley-Cox, Carol Coupland
Mar 2, 2011·PloS One·Julie A WomackUNKNOWN Veterans Aging Cohort Study Project Team
Nov 8, 2011·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Julia Hippisley-Cox, Carol Coupland
Nov 8, 2011·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Julia Hippisley-Cox, Carol Coupland
Apr 24, 2012·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Julia Hippisley-Cox, Carol Coupland
Apr 24, 2012·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Julia Hippisley-Cox, Carol Coupland
Apr 24, 2012·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Julia Hippisley-Cox, Carol Coupland
Jan 23, 2013·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Julia Hippisley-Cox, Carol Coupland

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Methods Mentioned

BETA
hormone replacement therapy
ICE

Software Mentioned

Stata
QFractureScore
QFractureScores

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