Predicting severe motor impairment in preterm children at age 5 years

Archives of Disease in Childhood
Anne SynnesCAP Trial Investigator group

Abstract

To determine whether the ability to predict severe motor impairment at age 5 years improves between birth and 18 months. Ancillary study of the Caffeine for Apnea of Prematurity Trial. International cohort of very low birth weight children who were assessed sequentially from birth to 5 years. Severe motor impairment was defined as a score <5th percentile on the Movement Assessment Battery of Children (MABC), or inability to complete the MABC because of cerebral palsy. Multivariable logistic regression cumulative risk models used four sets of predictor variables: early neonatal risk factors, risk factors at 36 weeks' postmenstrual age, risk factors at a corrected age of 18 months, and sociodemographic variables. A receiver operating characteristic curve (ROC) was generated for each model, and the four ROC curves were compared to determine if the addition of the new set of predictors significantly increased the area under the curve (AUC). Of 1469 children, 291 (19.8%) had a severe motor impairment at 5 years. The AUC increased from 0.650 soon after birth, to 0.718 (p<0.001) at 36 weeks' postmenstrual age, and to 0.797 at 18 months (p<0.001). Sociodemographic variables did not significantly improve the AUC (AUC=0.806; p=0.07). Pre...Continue Reading

Associated Clinical Trials

References

Jul 1, 1992·Journal of Child Psychology and Psychiatry, and Allied Disciplines·L HendersonS Henderson
Apr 1, 1997·Developmental Medicine and Child Neurology·R PalisanoB Galuppi
Oct 3, 1998·Journal of Child Psychology and Psychiatry, and Allied Disciplines·P H Wilson, B E McKenzie
Mar 8, 2003·JAMA : the Journal of the American Medical Association·Barbara SchmidtUNKNOWN Trial of Indomethacin Prophylaxis in Preterms (TIPP) Investigators
Dec 23, 2004·Archives of Disease in Childhood. Fetal and Neonatal Edition·R W I Cooke
May 19, 2006·The New England Journal of Medicine·Barbara SchmidtUNKNOWN Caffeine for Apnea of Prematurity Trial Group
Feb 9, 2007·Journal of the International Neuropsychological Society : JINS·Deborah DeweySusan G Crawford
Mar 21, 2007·Developmental Medicine and Child Neurology. Supplement·Peter RosenbaumBo Jacobsson
May 11, 2007·Developmental Medicine and Child Neurology·N M DavisUNKNOWN Victorian Infant Collaborative Study Group
Nov 9, 2007·The New England Journal of Medicine·Barbara SchmidtUNKNOWN Caffeine for Apnea of Prematurity Trial Group
Jul 19, 2008·The New England Journal of Medicine·Dag MosterTrond Markestad
Dec 17, 2009·Developmental Medicine and Child Neurology·Jacqueline WilliamsPeter J Anderson
Apr 7, 2010·Archives of Pediatrics & Adolescent Medicine·Peter J AndersonUNKNOWN Victorian Infant Collaborative Group
Jul 29, 2010·Obstetrics and Gynecology·Jobe G ShatrovGeorge L Mendz
Nov 26, 2010·Obstetrics and Gynecology·Vincenzo ZanardoSilvia Chiarelli
Jan 19, 2012·JAMA : the Journal of the American Medical Association·Barbara SchmidtUNKNOWN Caffeine for Apnea of Prematurity (CAP) Trial Investigators
Jun 19, 2012·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Jill G ZwickerLara A Boyd
Oct 16, 2012·Paediatric and Perinatal Epidemiology·Jin Liang ZhuAnnette W Olesen
Dec 25, 2012·Archives of Disease in Childhood·Jill Glennis ZwickerAnne R Synnes
May 29, 2013·Pediatrics·Garey H NoritzUNKNOWN Neuromotor Screening Expert Panel
May 21, 2014·The Journal of Pediatrics·Lex W DoyleUNKNOWN Caffeine for Apnea of Prematurity Trial investigators
Jan 3, 2015·Pediatrics·Susan R HintzUNKNOWN SUPPORT Study Group of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research

❮ Previous
Next ❯

Citations

Apr 14, 2016·Pediatric Research·Sirkku SetänenLeena Haataja
Feb 17, 2017·Journal of Perinatology : Official Journal of the California Perinatal Association·M A SteurerE E Rogers
Sep 19, 2017·Pediatric Research·Lauren L JantzieShenandoah Robinson
Oct 28, 2019·Journal of Pediatric Gastroenterology and Nutrition·Riikka J GunnarLaura Merras-Salmio

❮ Previous
Next ❯

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

© 2021 Meta ULC. All rights reserved