Predicting spike occurrence and neuronal responsiveness from LFPs in primary somatosensory cortex.

PloS One
Riccardo StorchiGabriele E M Biella

Abstract

Local Field Potentials (LFPs) integrate multiple neuronal events like synaptic inputs and intracellular potentials. LFP spatiotemporal features are particularly relevant in view of their applications both in research (e.g. for understanding brain rhythms, inter-areal neural communication and neuronal coding) and in the clinics (e.g. for improving invasive Brain-Machine Interface devices). However the relation between LFPs and spikes is complex and not fully understood. As spikes represent the fundamental currency of neuronal communication this gap in knowledge strongly limits our comprehension of neuronal phenomena underlying LFPs. We investigated the LFP-spike relation during tactile stimulation in primary somatosensory (S-I) cortex in the rat. First we quantified how reliably LFPs and spikes code for a stimulus occurrence. Then we used the information obtained from our analyses to design a predictive model for spike occurrence based on LFP inputs. The model was endowed with a flexible meta-structure whose exact form, both in parameters and structure, was estimated by using a multi-objective optimization strategy. Our method provided a set of nonlinear simple equations that maximized the match between models and true neurons i...Continue Reading

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Citations

Jul 21, 2015·Journal of Neuroscience Methods·Rotem RuachYifat Prut
Jan 9, 2019·Frontiers in Neural Circuits·Ayako HayashiKenichi Ohki
Jan 12, 2021·The Journal of Physiology·Patrycja Orlowska-FeuerRiccardo Storchi
Sep 26, 2021·Scientific Reports·Nur AhmadiChristos-Savvas Bouganis

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